When she was 20 years old, Mor Shapiro married Ben Shapiro. The couple was introduced by Ben's little sister, Abigail Shapiro, and hit it off immediately. They spent hours talking about free will and determinism on their first date. Ben and Mor got engaged three months into their relationship, and a month later held a wedding ceremony at Akko, Israel on July 8th, 2008.
On July 5th 2014, Mor gave birth to a daughter she named Leeya Eliana Shapiro.
Leeya means "I Belong To God" in Hebrew, while Eliana means "God Has Answered". She was born with a congenital heart defect called Atrial Septal Defect. On May 7th 2016,Mor gave birth to a son. In an open letter to his daughter, Ben mentioned how his wife had heroically been in labor for 26 hours. 
Shapiro finished her high school education at Sha’arei Mishpat College in Israel.
She is a Morrocan Jew. She later attended University of California, Los Angeles, where she her earned her B.S. and MD in Behavioral Neuroscience and Medicine. She spent two years doing developmental neuroscience research at the college, using fMRI to monitor childhood brain development. Mor also spent some time at David Geffen School of Medicine at UCLA.
Before getting married, Mor taught Hebrew and Judaism at the University Synagogue Sunday School in Los Angeles. She is a family physician at Kaiser Woodland Hills in Los Angeles, California. She has previously worked as a resident MD under the Family Medicine Residency Program at the Fontana, California based Kaiser Foundation Hospital.
She founded the DGSOM UCLA Ethics Symposium which occurs every year.