Born in Manchester,   she grew up in the Wigan suburb of Beech Hill and attended St John Fisher High.  She also, with the help of some of her friends, ran the tea club at Sacred Heart Catholic Church in Springfield,  but quit that in her early teens after discovering other things in life.  When she was 18, she had a breast implant operation and went from a 34A to a 34C.  After leaving school, she attended a local F.E. college and studied performing arts, business studies and psychology, but quit after just three months. 
After turning eighteen, Jayne got a job selling advertising for the Wigan Reporter newspaper, where she worked for three-and-a-half years.  After quitting that, she worked part-time as a fitness instructor while at the same time working as a glamour model. 
In 2007, Nikki Jayne visited the ETO Show in Birmingham, where she worked modelling evening gowns.  While there, she was introduced to Gazzman and Dave from Harmony Films.  Jayne saw a copy of the adult feature film Pirates and shared her desire to be in an adult film like it. 
Three days later,  she was in the Czech Republic filming her first scene  which was released as The Initiation of Nikki Jayne .  Nine months later, Jayne was contacted by LA Direct Models who invited her to come to Los Angeles ;  in June 2008, she signed a contract with Vivid Entertainment. 
Jayne was born Samantha Haywood in Manchester, England and was raised in Wigan, England.  Contrary to some reports, Jayne is not Wiccan ; this is partly due to a mix-up from people misreading Wigan.  Jayne states, "I come from a very open-minded family and they've always been supportive of my decisions, my aunt was a stripper and she probably inspired me because I always wanted to do something where I showed off my body. I'm probably a classic Gemini with both naughty and nice sides".