Morin (flavonol)
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Morin (flavonol)
Morin (flavonol)
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| Names | |
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| IUPAC name 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | |
| Other names Aurantica Al-Morin Morin hydrate Calico Yellow Toxylon pomiferum Bois d'arc Osage orange extract | |
| Identifiers | |
CAS Number |
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3D model (JSmol) |
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| ChEBI |
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| ChEMBL |
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| ChemSpider |
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| ECHA InfoCard | 100.006.858 [19] |
IUPHAR/BPS |
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| KEGG |
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PubChemCID |
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CompTox Dashboard(EPA) |
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InChI
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SMILES
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| Properties | |
| C15H10O7 | |
| Molar mass | 302.238 g·mol−1 |
| Density | 1.799 g/mL |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify [24] (what is  ?) | |
| Infobox references | |
Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic), and from leaves of Psidium guajava (common guava).[1] In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM.[2] Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregate amyloid fibers.[3]
Morin exhibit inhibitory action against IgE-mediated allergic response. Morin treatment significantly down-regulated expressions of BLT2, NF-κB, and Th2-cytokine (TNF-α, IL-1β, IL-4, IL-6, and IL-13) in lungs of murine model of allergic asthma.[4]
Morin can be used to test for the presence of aluminium or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.
| |
| Names | |
|---|---|
| IUPAC name 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | |
| Other names Aurantica Al-Morin Morin hydrate Calico Yellow Toxylon pomiferum Bois d'arc Osage orange extract | |
| Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
| ChEBI |
|
| ChEMBL |
|
| ChemSpider |
|
| ECHA InfoCard | 100.006.858 [19] |
IUPHAR/BPS |
|
| KEGG |
|
PubChemCID |
|
CompTox Dashboard(EPA) |
|
InChI
| |
SMILES
| |
| Properties | |
| C15H10O7 | |
| Molar mass | 302.238 g·mol−1 |
| Density | 1.799 g/mL |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify [24] (what is ?) | |
| Infobox references | |
References
[1]
Citation Link//doi.org/10.1016%2Fj.fitote.2007.03.015Rattanachaikunsopon, Pongsak; Phumkhachorn, Parichat (2007). "Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens". Fitoterapia. 78 (6): 434–436. doi:10.1016/j.fitote.2007.03.015.
Sep 27, 2019, 8:29 AM
[2]
Citation Link//doi.org/10.2174%2F092986706776361012Tian, Wei-Xi (2006). "Inhibition of Fatty Acid Synthase by Polyphenols". Current Medicinal Chemistry. 13 (8): 967–977. doi:10.2174/092986706776361012.
Sep 27, 2019, 8:29 AM
[3]
Citation Link//www.ncbi.nlm.nih.gov/pmc/articles/PMC3375438Noor, Harris; Cao, Ping; Raleigh, Daniel P. (2012). "Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers". Protein Science. 21 (3): 373–382. doi:10.1002/pro.2023. PMC 3375438.
Sep 27, 2019, 8:29 AM
[4]
Citation Link//doi.org/10.2174%2F1874467212666190102105052Kandhare, Amit D.; Liu, Zihao; Mukherjee, Anwesha A.; Bodhankar, Subhash L. (2019). "Therapeutic Potential of Morin in Ovalbumin-induced Allergic Asthma Via Modulation of SUMF2/IL-13 and BLT2/NF-kB Signaling Pathway". Current Molecular Pharmacology. 12 (2): 122–138. doi:10.2174/1874467212666190102105052.
Sep 27, 2019, 8:29 AM