She was born in Bowling Green, Kentucky, United States. Before entering the adult entertainment industry she was a college student, and earned a Master of Arts degree in Multimedia with a minor in Business at the University of Kentucky during the 2002 school year. To pay her way through college, she worked in and managed a hair salon.
She entered the industry in 2002 by creating her own web site, LisaSparxxx.com. She made her debut the following year in a video release entitled Dirtier Debutantes #4 ( 2003) with Ed Powers. From 2002–04 she also hosted KSEX Radio. There was some speculation that she has retired, but in an interview Sparks stated she was just busy and had no plans of leaving the industry.
Sparxxx appeared in Season 2 of The WB's The Surreal Life , where it was edited so that it seemed to be offering Erik Estrada oral sex. This took place during Ron Jeremy's topless porn-star pool party. She also appeared in hip hop artist Murs' music video "Risky Business" featuring Shock G off of his record The End of the Beginning , along with fellow actress Olivia O'Lovely.
Lisa Sparxxx played Meiko in The Witch's Sabbath ( 2005), a horror film by director Jeff Leroy.
Her bust measurements are 38FF.