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Epstein–Barr virus nuclear antigen 3

Epstein–Barr virus nuclear antigen 3

The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus.

  • EBNA-3A

  • EBNA-3B

  • EBNA-3C

These genes also bind the host RBP-Jκ protein.

EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).[1][2]

References

[1]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/15713632Knight JS, Sharma N, Robertson ES (2005). "SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen". Mol. Cell. Biol. 25 (5): 1749–63. doi:10.1128/MCB.25.5.1749-1763.2005. PMC 549383. PMID 15713632.
Sep 30, 2019, 2:32 AM
[2]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/16352731Knight JS, Sharma N, Robertson ES (2005). "Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18562–6. doi:10.1073/pnas.0503886102. PMC 1317900. PMID 16352731.
Sep 30, 2019, 2:32 AM
[3]
Citation Linkwww.ncbi.nlm.nih.gov"SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen"
Sep 30, 2019, 2:32 AM
[4]
Citation Linkdoi.org10.1128/MCB.25.5.1749-1763.2005
Sep 30, 2019, 2:32 AM
[5]
Citation Linkwww.ncbi.nlm.nih.gov549383
Sep 30, 2019, 2:32 AM
[6]
Citation Linkwww.ncbi.nlm.nih.gov15713632
Sep 30, 2019, 2:32 AM
[7]
Citation Linkwww.ncbi.nlm.nih.gov"Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase"
Sep 30, 2019, 2:32 AM
[8]
Citation Linkdoi.org10.1073/pnas.0503886102
Sep 30, 2019, 2:32 AM
[9]
Citation Linkwww.ncbi.nlm.nih.gov1317900
Sep 30, 2019, 2:32 AM
[10]
Citation Linkwww.ncbi.nlm.nih.gov16352731
Sep 30, 2019, 2:32 AM
[11]
Citation Linken.wikipedia.orgThe original version of this page is from Wikipedia, you can edit the page right here on Everipedia.Text is available under the Creative Commons Attribution-ShareAlike License.Additional terms may apply.See everipedia.org/everipedia-termsfor further details.Images/media credited individually (click the icon for details).
Sep 30, 2019, 2:32 AM