CD64 (biology)
CD64 (biology)
| Fc fragment of IgG, high affinity Ia, receptor (CD64) | |
|---|---|
| Identifiers | |
| Symbol | FCGR1A |
| NCBI gene | 2209 [8] |
| HGNC | 3613 [9] |
| OMIM | 146760 [10] |
| RefSeq | NM_000566 [11] |
| UniProt | P12314 [12] |
| Other data | |
| Locus | Chr. 1 *q21.2-21.3 [13] * |
| Fc fragment of IgG, high affinity Ib, receptor (CD64) | |
| Identifiers | |
| Symbol | FCGR1B |
| NCBI gene | 2210 [14] |
| HGNC | 3614 [15] |
| OMIM | 601502 [16] |
| RefSeq | NM_001004340 [17] |
| UniProt | Q92637 [18] |
| Other data | |
| Locus | Chr. 1 *p11.2 [19] * |
| Fc fragment of IgG, high affinity Ic, receptor (CD64) | |
| Identifiers | |
| Symbol | FCGR1C |
| NCBI gene | 2211 [20] |
| HGNC | 3615 [21] |
| OMIM | 601503 [22] |
| RefSeq | XM_001133198 [23] |
| Other data | |
| Locus | Chr. 1 *q21.1 [24] * |
CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity.[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.[2]
Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.[3]
There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1.[6] These three genes produce six different mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.[3]
| Fc fragment of IgG, high affinity Ia, receptor (CD64) | |
|---|---|
| Identifiers | |
| Symbol | FCGR1A |
| NCBI gene | 2209 [8] |
| HGNC | 3613 [9] |
| OMIM | 146760 [10] |
| RefSeq | NM_000566 [11] |
| UniProt | P12314 [12] |
| Other data | |
| Locus | Chr. 1 *q21.2-21.3 [13] * |
| Fc fragment of IgG, high affinity Ib, receptor (CD64) | |
| Identifiers | |
| Symbol | FCGR1B |
| NCBI gene | 2210 [14] |
| HGNC | 3614 [15] |
| OMIM | 601502 [16] |
| RefSeq | NM_001004340 [17] |
| UniProt | Q92637 [18] |
| Other data | |
| Locus | Chr. 1 *p11.2 [19] * |
| Fc fragment of IgG, high affinity Ic, receptor (CD64) | |
| Identifiers | |
| Symbol | FCGR1C |
| NCBI gene | 2211 [20] |
| HGNC | 3615 [21] |
| OMIM | 601503 [22] |
| RefSeq | XM_001133198 [23] |
| Other data | |
| Locus | Chr. 1 *q21.1 [24] * |