2-aminoethylphosphonate—pyruvate transaminase

2-aminoethylphosphonate—pyruvate transaminase

2-aminoethylphosphonate-pyruvate transaminase | |||||||||
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Identifiers | |||||||||
EC number | 2.6.1.37 [9] | ||||||||
CAS number | 37277-91-1 [10] | ||||||||
Databases | |||||||||
IntEnz | IntEnz view [11] | ||||||||
BRENDA | BRENDA entry [12] | ||||||||
ExPASy | NiceZyme view [13] | ||||||||
KEGG | KEGG entry [14] | ||||||||
MetaCyc | metabolic pathway [15] | ||||||||
PRIAM | profile [16] | ||||||||
PDB structures | RCSB PDB [17] PDBe [18] PDBsum [19] | ||||||||
Gene Ontology | AmiGO [20] / QuickGO [21] | ||||||||
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Search | |||||||||
PMC | articles [22] | ||||||||
PubMed | articles [23] | ||||||||
NCBI | proteins [24] |
In enzymology, a 2-aminoethylphosphonate—pyruvate transaminase (EC 2.6.1.37 [25] ) is an enzyme that catalyzes the chemical reaction
- (2-aminoethyl)phosphonate + pyruvate
Thus, the two substrates of this enzyme are (2-aminoethyl)phosphonate and pyruvate, whereas its two products are 2-phosphonoacetaldehyde and L-alanine.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is (2-aminoethyl)phosphonate:pyruvate aminotransferase. Other names in common use include (2-aminoethyl)phosphonate transaminase, (2-aminoethyl)phosphonate aminotransferase, (2-aminoethyl)phosphonic acid aminotransferase, 2-aminoethylphosphonate-pyruvate aminotransferase, 2-aminoethylphosphonate aminotransferase, 2-aminoethylphosphonate transaminase, AEP transaminase, and AEPT. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, pyridoxal phosphate.
2-aminoethylphosphonate-pyruvate transaminase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 2.6.1.37 [9] | ||||||||
CAS number | 37277-91-1 [10] | ||||||||
Databases | |||||||||
IntEnz | IntEnz view [11] | ||||||||
BRENDA | BRENDA entry [12] | ||||||||
ExPASy | NiceZyme view [13] | ||||||||
KEGG | KEGG entry [14] | ||||||||
MetaCyc | metabolic pathway [15] | ||||||||
PRIAM | profile [16] | ||||||||
PDB structures | RCSB PDB [17] PDBe [18] PDBsum [19] | ||||||||
Gene Ontology | AmiGO [20] / QuickGO [21] | ||||||||
| |||||||||
Search | |||||||||
PMC | articles [22] | ||||||||
PubMed | articles [23] | ||||||||
NCBI | proteins [24] |
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1M32 [26] .