2-aminoethylphosphonate—pyruvate transaminase
2-aminoethylphosphonate—pyruvate transaminase
| 2-aminoethylphosphonate-pyruvate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.37 [9] | ||||||||
| CAS number | 37277-91-1 [10] | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view [11] | ||||||||
| BRENDA | BRENDA entry [12] | ||||||||
| ExPASy | NiceZyme view [13] | ||||||||
| KEGG | KEGG entry [14] | ||||||||
| MetaCyc | metabolic pathway [15] | ||||||||
| PRIAM | profile [16] | ||||||||
| PDB structures | RCSB PDB [17] PDBe [18] PDBsum [19] | ||||||||
| Gene Ontology | AmiGO [20] / QuickGO [21] | ||||||||
| |||||||||
| Search | |||||||||
| PMC | articles [22] | ||||||||
| PubMed | articles [23] | ||||||||
| NCBI | proteins [24] | ||||||||
In enzymology, a 2-aminoethylphosphonate—pyruvate transaminase (EC 2.6.1.37 [25] ) is an enzyme that catalyzes the chemical reaction
- (2-aminoethyl)phosphonate + pyruvate2-phosphonoacetaldehyde + L-alanine
Thus, the two substrates of this enzyme are (2-aminoethyl)phosphonate and pyruvate, whereas its two products are 2-phosphonoacetaldehyde and L-alanine.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is (2-aminoethyl)phosphonate:pyruvate aminotransferase. Other names in common use include (2-aminoethyl)phosphonate transaminase, (2-aminoethyl)phosphonate aminotransferase, (2-aminoethyl)phosphonic acid aminotransferase, 2-aminoethylphosphonate-pyruvate aminotransferase, 2-aminoethylphosphonate aminotransferase, 2-aminoethylphosphonate transaminase, AEP transaminase, and AEPT. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, pyridoxal phosphate.
| 2-aminoethylphosphonate-pyruvate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.37 [9] | ||||||||
| CAS number | 37277-91-1 [10] | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view [11] | ||||||||
| BRENDA | BRENDA entry [12] | ||||||||
| ExPASy | NiceZyme view [13] | ||||||||
| KEGG | KEGG entry [14] | ||||||||
| MetaCyc | metabolic pathway [15] | ||||||||
| PRIAM | profile [16] | ||||||||
| PDB structures | RCSB PDB [17] PDBe [18] PDBsum [19] | ||||||||
| Gene Ontology | AmiGO [20] / QuickGO [21] | ||||||||
| |||||||||
| Search | |||||||||
| PMC | articles [22] | ||||||||
| PubMed | articles [23] | ||||||||
| NCBI | proteins [24] | ||||||||
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1M32 [26] .