The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.
|, C-Rel, REL proto-oncogene, NF-kB subunit|
|Genetically Related Diseases|
|rheumatoid arthritis, psoriatic arthritis|
|RNA expression pattern|
|View/Edit Human||View/Edit Mouse|