Growing up, Duke shared a room with his father, which doubled as a studio.
Duke started to play with a beat pad when he was 5 years old.
In 2017, “Whole Lotta” became his first song to become a hit with the help of well-known Atlanta dancer SheLovesMeechie. Meechie made a video to the song which helped it go viral. Offset of Migos caught wind of the song because of the dancer’s work. Offset reached out to Duke on Instagram, although Duke thought the message was fake it was real. After talking, Offset signed Duke Deuce to the Migos' Quality Control label. 
In 2018, he released his mixtape Memphis Massacre. Two of his songs were included in QC’s Control The Streets Volume 2 compilation—"Yeh" and “Grab A…”.
In 2019, he released “Crunk Ain’t Dead" which received over 11 million views on YouTube. He later released Memphis Massacre 2, which features the “Crunk Ain’t Dead (Remix)” with Lil Jon, Juicy J and Project Pat.
Duke has over 103,000 subscribers on his YouTube channel, over 457,000 followers on Instagram and over 9,000 followers on Soundcloud.