Everipedia Logo
Everipedia is now IQ.wiki - Join the IQ Brainlist and our Discord for early access to editing on the new platform and to participate in the beta testing.
dCTP deaminase (dUMP-forming)

dCTP deaminase (dUMP-forming)

In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30 [16] ) is an enzyme that catalyzes the chemical reaction

dCTP + 2 H2OdUMP + diphosphate + NH3

Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

DCTP deaminase (dUMP-forming)
Identifiers
EC number3.5.4.30 [3]
Databases
IntEnzIntEnz view [4]
BRENDABRENDA entry [5]
ExPASyNiceZyme view [6]
KEGGKEGG entry [7]
MetaCycmetabolic pathway [8]
PRIAMprofile [9]
PDB structuresRCSB PDB [10] PDBe [11] PDBsum [12]
Search
PMCarticles [13]
PubMedarticles [14]
NCBIproteins [15]

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB [17] , 2HXD [18] , and 2HXE [19] .

References

[1]
Citation Link//doi.org/10.1074%2Fjbc.M21246020010.1074/jbc.M212460200
Sep 30, 2019, 9:06 AM
[2]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/1253864812538648
Sep 30, 2019, 9:06 AM
[3]
Citation Linkwww.qmul.ac.uk3.5.4.30
Sep 30, 2019, 9:06 AM
[4]
Citation Linkwww.ebi.ac.ukIntEnz view
Sep 30, 2019, 9:06 AM
[5]
Citation Linkwww.brenda-enzymes.orgBRENDA entry
Sep 30, 2019, 9:06 AM
[6]
Citation Linkwww.expasy.orgNiceZyme view
Sep 30, 2019, 9:06 AM
[7]
Citation Linkwww.genome.jpKEGG entry
Sep 30, 2019, 9:06 AM
[8]
Citation Linkbiocyc.orgmetabolic pathway
Sep 30, 2019, 9:06 AM
[9]
Citation Linkpriam.prabi.frprofile
Sep 30, 2019, 9:06 AM
[10]
Citation Linkwww.rcsb.orgRCSB PDB
Sep 30, 2019, 9:06 AM
[11]
Citation Linkwww.ebi.ac.ukPDBe
Sep 30, 2019, 9:06 AM
[12]
Citation Linkwww.ebi.ac.ukPDBsum
Sep 30, 2019, 9:06 AM
[13]
Citation Linkwww.ncbi.nlm.nih.govarticles
Sep 30, 2019, 9:06 AM
[14]
Citation Linkwww.ncbi.nlm.nih.govarticles
Sep 30, 2019, 9:06 AM
[15]
Citation Linkwww.ncbi.nlm.nih.govproteins
Sep 30, 2019, 9:06 AM
[16]
Citation Linkenzyme.expasy.org3.5.4.30
Sep 30, 2019, 9:06 AM
[17]
Citation Linkwww.ebi.ac.uk2HXB
Sep 30, 2019, 9:06 AM
[18]
Citation Linkwww.ebi.ac.uk2HXD
Sep 30, 2019, 9:06 AM
[19]
Citation Linkwww.ebi.ac.uk2HXE
Sep 30, 2019, 9:06 AM
[20]
Citation Linkdoi.org10.1074/jbc.M212460200
Sep 30, 2019, 9:06 AM