Alfamega was born in Bankhead, Atlanta, Georgia, and he grew up in Techwood Homes, Atlanta. Alfamega started rapping in a small USP federal Atlanta prison cell. Despite being locked away from society, incarceration caused Alfamega's creative spirit to soar. While serving his seven years imprisonment, which started in 1995, he completed seventeen hundred songs, three screen plays and penned a non-fiction book.
After being released in 2002, he took the 1,700 songs he wrote while incarcerated to a family friend, Beanie Sigel. Sigel was interested, he offered Alfamega a recording but couldn't seal the deal. Six months later Alfamega collaborated on a song with David Banner which led to a deal with Universal Records.
In 2003, Alfamega began working on his own album.
Also in 2003, Alfamega recorded "South of the Mason Dixon", "Holla" (featuring Jody Breeze ) and "A Town Stomp" (featuring Lil Jon).
In 2004, Alfamega was released from his recording contract with Universal Records for undisclosed reasons.
Alfamega kept moving forward and for the rest of 2004 until 2006, Alfamega was featured on over three hundred and fifty mix CDs and hosted over one hundred mix CDs across the country.
He was also featured in Smooth Magazine twice, XXL (twice), The Source (Off the Radar), Lap Dance (Cover), Juice Magazine and Crunk Magazine.
In 2005, he signed with Grand Hustle Records and joined label boss T.I. on tour. Three years later the label released the hard-hitting club number "Uh Huh" as the first single from his debut album I Am Alfamega. He planned to released the album in January 2008 but was postponed due to an issue between Alfamega and T.I. He later released the album on October 14, 2008.
In 2009, he collaborated with Lonnie Mack and World Cake to work on the single "Like This Here" from Makell Bird Presents and also worked with Juice on "Everybody Knows Me" from Position of Power Records.
T.I. Drops Rapper Alfamega From Grand Hustle Label
He booted fellow rapper Alfamega from his Grand Hustle Records following a published report by SmokingGun.com that claims Alfamega was an informant for the drug enforcement administration during a trial on a heroin trafficker: 
"He essentially deceived us by failing to fully disclose the truth about his past, and there is no place in our organization for dishonest and misleading behavior.
As I have always said, you must take responsibility for your own actions.
We at Grand Hustle can not support or condone the blaming of others for our own mistakes.
I hope and pray to God, bless his savings plans, but I don't foresee me or my company playing a role in his personal or professional business."
T.I., born Clifford Harris, said during an interview on Atlanta’s 107.9 radio station.