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Sperm

Sperm

Sperm is the male reproductive cell. In the types of sexual reproduction known as anisogamy and its subtype oogamy, there is a marked difference in the size of the gametes with the smaller one being termed the "male" or sperm cell. A uniflagellar sperm cell that is motile is referred to as aspermatozoon, whereas a non-motile sperm cell is referred to as a spermatium. Sperm cells cannot divide and have a limited life span, but after fusion with egg cells during fertilization, a new organism begins developing, starting as a totipotent zygote. The human sperm cell is haploid, so that its 23 chromosomes can join the 23 chromosomes of the female egg to form a diploid cell. In mammals, sperm develops in the testicles, is stored in the epididymis, and released from the penis.

The word "sperm" is derived from the Greek word (σπέρμα) sperma (meaning "seed").

Sperm in animals

Function

The main sperm function is to reach the ovum and fuse with it to deliver two sub-cellular structures: (i) the male pronucleus that contains the genetic material and (ii) the centrioles that are structures that help organize the microtubule cytoskeleton.

Anatomy

The mammalian sperm cell can be divided in 2 parts:

  • head: contains the nucleus with densely coiled chromatin fibers, surrounded anteriorly by a thin, flattened sac called the acrosome, which contains enzymes used for penetrating the female egg. It also contains vacuoles.[1]

  • tail: also called the flagellum, is the longest part and capable of wave-like motion that propels sperm for swimming and aids in the penetration of the egg.

  • Sperm motility depends on the 4 parts of the tail: connecting piece, midpiece, principal piece, and the end piece.[2][3]

The neck or connecting piece contains one typical centriole and one atypical centriole such as the proximal centriole like.[4][5]

The midpiece has a central filamentous core with many mitochondria spiralled around it, used for ATP production for the journey through the female cervix, uterus and uterine tubes.

The tail or "flagellum"executes the lashing movements that propel the spermatocyte.[6]

During fertilization, the sperm provides three essential parts to the oocyte: (1) a signalling or activating factor, which causes the metabolically dormant oocyte to activate; (2) the haploid paternal genome; (3) the centriole, which is responsible for forming the centrosome and microtubule system.[7]

Origin

The spermatozoa of animals are produced through spermatogenesis inside the male gonads (testicles) via meiotic division. The initial spermatozoon process takes around 70 days to complete. In the spermatid stage, the sperm develops the familiar tail. The next stage where it becomes fully mature takes around 60 days when it is called a spermatozoan.[8] Sperm cells are carried out of the male body in a fluid known as semen. Human sperm cells can survive within the female reproductive tract for more than 5 days post coitus.[9] Semen is produced in the seminal vesicles, prostate gland and urethral glands.

In 2016 scientists at Nanjing Medical University claimed they had produced cells resembling mouse spermatids artificially from stem cells. They injected these spermatids into mouse eggs and produced pups.[10]

Sperm quality

Sperm quantity and quality are the main parameters in semen quality, which is a measure of the ability of semen to accomplish fertilization. Thus, in humans, it is a measure of fertility in a man. The genetic quality of sperm, as well as its volume and motility, all typically decrease with age.[11] (See paternal age effect.)

DNA damages present in sperm cells in the period after meiosis but before fertilization may be repaired in the fertilized egg, but if not repaired, can have serious deleterious effects on fertility and the developing embryo. Human sperm cells are particularly vulnerable to free radical attack and the generation of oxidative DNA damage.[12] (see e.g. 8-Oxo-2'-deoxyguanosine)

The postmeiotic phase of mouse spermatogenesis is very sensitive to environmental genotoxic agents, because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage.[13] Irradiation of male mice during late spermatogenesis can induce damage that persists for at least 7 days in the fertilizing sperm cells, and disruption of maternal DNA double-strand break repair pathways increases sperm cell-derived chromosomal aberrations.[14] Treatment of male mice with melphalan, a bifunctional alkylating agent frequently employed in chemotherapy, induces DNA lesions during meiosis that may persist in an unrepaired state as germ cells progress though DNA repair-competent phases of spermatogenic development.[15] Such unrepaired DNA damages in sperm cells, after fertilization, can lead to offspring with various abnormalities.

Sperm size

Related to sperm quality is sperm size, at least in some animals.

For instance, the sperm of some species of fruit fly (Drosophila) are up to 5.8 cm long — about 20 times as long as the fly itself. Longer sperm cells are better than their shorter counterparts at displacing competitors from the female’s seminal receptacle. The benefit to females is that only healthy males carry ‘good’ genes that can produce long sperm in sufficient quantities to outcompete their competitors.[16][17]

Market for human sperm

Some sperm banks hold up to 170 litres (37 imp gal; 45 US gal) of sperm.[18]

In addition to ejaculation, it is possible to extract sperm through TESE.

On the global market, Denmark has a well-developed system of human sperm export. This success mainly comes from the reputation of Danish sperm donors for being of high quality[19] and, in contrast with the law in the other Nordic countries, gives donors the choice of being either anonymous or non-anonymous to the receiving couple.[19] Furthermore, Nordic sperm donors tend to be tall and highly educated[20] and have altruistic motives for their donations,[20] partly due to the relatively low monetary compensation in Nordic countries. More than 50 countries worldwide are importers of Danish sperm, including Paraguay, Canada, Kenya, and Hong Kong.[19] However, the Food and Drug Administration (FDA) of the US has banned import of any sperm, motivated by a risk of transmission of Creutzfeldt–Jakob disease, although such a risk is insignificant, since artificial insemination is very different from the route of transmission of Creutzfeldt–Jakob disease.[21] The prevalence of Creutzfeldt–Jakob disease for donors is at most one in a million, and if the donor was a carrier, the infectious proteins would still have to cross the blood-testis barrier to make transmission possible.[21]

History

Sperm were first observed in 1677 by Antonie van Leeuwenhoek[22] using a microscope. He described them as being animalcules (little animals), probably due to his belief in preformationism, which thought that each sperm contained a fully formed but small human.

Forensic analysis

Ejaculated fluids are detected by ultraviolet light, irrespective of the structure or colour of the surface.[23] Sperm heads, e.g. from vaginal swabs, are still detected by microscopy using the "Christmas Tree Stain" method, i.e., Kernechtrot-Picroindigocarmine (KPIC) staining.[24][25]

Sperm in plants

Sperm cells in algal and many plant gametophytes are produced in male gametangia (antheridia) via mitotic division. In flowering plants, sperm nuclei are produced inside pollen.

Motile sperm cells

Motile sperm cells typically move via flagella and require a water medium in order to swim toward the egg for fertilization. In animals most of the energy for sperm motility is derived from the metabolism of fructose carried in the seminal fluid. This takes place in the mitochondria located in the sperm's midpiece (at the base of the sperm head). These cells cannot swim backwards due to the nature of their propulsion. The uniflagellated sperm cells (with one flagellum) of animals are referred to asspermatozoa

Motile sperm are also produced by many protists and the gametophytes of bryophytes, ferns and some gymnosperms such as cycads and ginkgo. The sperm cells are the only flagellated cells in the life cycle of these plants. In many ferns and lycophytes, they are multi-flagellated (carrying more than one flagellum).[26]

In nematodes, the sperm cells are amoeboid and crawl, rather than swim, towards the egg cell.[27]

Non-motile sperm cells

Non-motile sperm cells called spermatia lack flagella and therefore cannot swim. Spermatia are produced in a spermatangium.[26]

Because spermatia cannot swim, they depend on their environment to carry them to the egg cell.

Some red algae, such as Polysiphonia, produce non-motile spermatia that are spread by water currents after their release.[26] The spermatia of rust fungi are covered with a sticky substance. They are produced in flask-shaped structures containing nectar, which attract flies that transfer the spermatia to nearby hyphae for fertilization in a mechanism similar to insect pollination in flowering plants.[28]

Fungal spermatia (also called pycniospores, especially in the Uredinales) may be confused with conidia. Conidia are spores that germinate independently of fertilization, whereas spermatia are gametes that are required for fertilization. In some fungi, such as Neurospora crassa, spermatia are identical to microconidia as they can perform both functions of fertilization as well as giving rise to new organisms without fertilization.[29]

Sperm nuclei

In almost all embryophytes, including most gymnosperms and all angiosperms, the male gametophytes (pollen grains) are the primary mode of dispersal, for example via wind or insect pollination, eliminating the need for water to bridge the gap between male and female. Each pollen grain contains a spermatogenous (generative) cell. Once the pollen lands on the stigma of a receptive flower, it germinates and starts growing a pollen tube through the carpel. Before the tube reaches the ovule, the nucleus of the generative cell in the pollen grain divides and gives rise to two sperm nuclei, which are then discharged through the tube into the ovule for fertilization.[26]

In some protists, fertilization also involves sperm nuclei, rather than cells, migrating toward the egg cell through a fertilization tube. Oomycetes form sperm nuclei in a syncytical antheridium surrounding the egg cells. The sperm nuclei reach the eggs through fertilization tubes, similar to the pollen tube mechanism in plants.[26]

Sperm centrioles

Most sperm cells have centrioles in the sperm neck.[30] Sperm of many animals has 2 typical centrioles known as the proximal centriole and distal centriole. Some animals like human and bovine have a single typical centriole, known as the proximal centriole, and a second centriole with atypical structure.[4] Mice and rats have no recognizable sperm centrioles. The fruit fly Drosophila melanogaster has a single centriole and an atypical centriole named the Proximal Centriole-Like (PCL).[5]

Sperm tail formation

The sperm tail is a specialized type of cilium (aka flagella). In many animals the sperm tail is formed in a unique way, which is named Cytosolic ciliogenesis, since all or part of axoneme of the sperm tail is formed in the cytoplasm or get exposed to the cytoplasm.[32]

See also

  • Mendelian inheritance

  • Ejaculation

  • Female sperm

  • Female sperm storage

  • Polyspermy

  • Sperm competition

  • Sperm donation

  • Sperm granuloma

  • Spermatogenesis

  • Spermatozoon

References

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Citation Linkopenlibrary.orgFawcett, D. W. (1981) Sperm Flagellum. In: The Cell. D. W. Fawcett. Philadelphia, W. B. Saunders Company. 14: pp. 604-640.
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Citation Linkopenlibrary.orgLehti, M. S. and A. Sironen (2017). "Formation and function of sperm tail structures in association with sperm motility defects." Bi
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Citation Link//www.ncbi.nlm.nih.gov/pubmed/29880810Fishman, Emily L; Jo, Kyoung; Nguyen, Quynh P. H; Kong, Dong; Royfman, Rachel; Cekic, Anthony R; Khanal, Sushil; Miller, Ann L; Simerly, Calvin; Schatten, Gerald; Loncarek, Jadranka; Mennella, Vito; Avidor-Reiss, Tomer (2018). "A novel atypical sperm centriole is functional during human fertilization". Nature Communications. 9 (1): 2210. doi:10.1038/s41467-018-04678-8. PMC 5992222. PMID 29880810.
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Citation Link//www.ncbi.nlm.nih.gov/pubmed/19293139Blachon, S; Cai, X; Roberts, K. A; Yang, K; Polyanovsky, A; Church, A; Avidor-Reiss, T (2009). "A Proximal Centriole-Like Structure is Present in Drosophila Spermatids and Can Serve as a Model to Study Centriole Duplication". Genetics. 182 (1): 133–44. doi:10.1534/genetics.109.101709. PMC 2674812. PMID 19293139.
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Citation Link//doi.org/10.1002%2Fmrd.1120130302Ishijima, Sumio; Oshio, Shigeru; Mohri, Hideo (1986). "Flagellar movement of human spermatozoa". Gamete Research. 13 (3): 185–197. doi:10.1002/mrd.1120130302.
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Citation Linkbooks.google.comHewitson, Laura & Schatten, Gerald P. (2003). "The biology of fertilization in humans". In Patrizio, Pasquale et al. (eds.). A color atlas for human assisted reproduction: laboratory and clinical insights. Lippincott Williams & Wilkins. p. 3. ISBN 978-0-7817-3769-2. Retrieved 2013-11-09.CS1 maint: uses editors parameter (link)
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Citation Link//www.ncbi.nlm.nih.gov/pubmed/6518230Gould, JE; Overstreet, JW; Hanson, FW (1984). "Assessment of human sperm function after recovery from the female reproductive tract". Biology of Reproduction. 31 (5): 888–894. doi:10.1095/biolreprod31.5.888. PMID 6518230.
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Citation Link//doi.org/10.1038%2Fnature.2016.19453Cyranoski, David (2016). "Researchers claim to have made artificial mouse sperm in a dish". Nature. doi:10.1038/nature.2016.19453.
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Citation Linkinfertility.about.comGurevich, Rachel (2008-06-10). "Does Age Affect Male Fertility?". About.com. Retrieved 14 February 2010.
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[12]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/26178844Gavriliouk D, Aitken RJ (2015). "Damage to Sperm DNA Mediated by Reactive Oxygen Species: Its Impact on Human Reproduction and the Health Trajectory of Offspring". Advances in Experimental Medicine and Biology. 868: 23–47. doi:10.1007/978-3-319-18881-2_2. ISBN 978-3-319-18880-5. PMID 26178844. Cite journal requires |journal= (help)
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Citation Link//www.ncbi.nlm.nih.gov/pubmed/18282746Marchetti F, Wyrobek AJ (2008). "DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage". DNA Repair. 7 (4): 572–81. doi:10.1016/j.dnarep.2007.12.011. PMID 18282746.
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Citation Linkwww.theguardian.comSarfraz Manzoor (2 November 2012). "Come inside: the world's biggest sperm bank". The Guardian. Retrieved 4 August 2013.
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[19]
Citation Linkwww.norden.orgAssisted Reproduction in the Nordic Countries ncbio.org
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Citation Linkwww.newser.comFDA Rules Block Import of Prized Danish Sperm Posted Aug 13, 08 7:37 AM CDT in World, Science & Health
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