High school and college career
Louis played football at Miami Beach Senior High School, where he played at quarterback, running back, wide receiver, tight end, linebacker, and safety.  Excellent at all positions, his best performances came at a running back and receiver.  In his senior year, he had 14 offensive touchdowns and 60 defensive tackles.  ESPN ranked him the 21st best high school player in the nation in 2012. 
Louis wavered in the college draft. He initially committed to Auburn University, then broke the commitment and committed to Florida State University. He broke that commitment as well, and finally agreed to play for Auburn. 
Louis "was not nearly as productive" in college as in high school.  Although he often started games, he was never a full-time starter.  His most memorable play was a 78-yard (71 m) touchdown reception against the Georgia Bulldogs in 2013, known as the " Prayer at Jordan-Hare ".  The catch enabled the Tigers to win their division, enter the post-season, and make it into a national championship game.  He led the Tigers in receptions (46 for 716 yards (655 m)) and touchdowns (three) as a senior.  Louis ended his career at Auburn in 2015 with 98 receptions out of 117 touches for 1,338 yards (1,223 m) and eight touchdowns.  Louis' collegiate career was also plagued by dropped passes, and he had six fumbles. 
Louis attended the NFL Scouting Combine in February 2016. His performance there—an 11-foot (3.4 m) broad jump (best among all attending wide receivers), a 40-yard dash of 4.43 seconds, and a vertical jump of 38 inches (0.97 m)—won him widespread attention, and significantly boosted his chances in the coming draft. 
The Cleveland Browns drafted Louis in the fourth round, 114th overall, in the 2016 NFL Draft.  On May 31, he signed a four-year contract worth about $2.9 million, which included a signing bonus worth about $568,000. 
Louis incurred a hamstring injury during practice on August 13, keeping him out of the rest of the preseason.