Nicolás "Nico" Brussino (born 2 March 1993) is an Argentine-Italian professional basketball player for Basket Zaragoza of the Spanish Liga ACB. He also represents the senior Argentine national basketball team. Standing at 2.01 m (6 ft 7 in), he mainly plays as a small forward.

After two years playing for San Martín de Marcos Juárez,^[2] Brussino joined Regatas Corrientes on July 22, 2012.^[3] Prior to the 2012–13 season, it was discovered that Brussino had a heart problem, a congenital disease that saw an abnormal electrical connection between the atria and ventricles.^[4] Despite this, he still managed 29 games for Corrientes, averaging 1.9 points and 1.1 rebounds per game, while helping Corrientes win the 2012–13 LNB championship.

In 2013–14, Brussino averaged 6.0 points and 2.6 rebounds in 55 games, and in 2014–15, he again played in 55 games and averaged 9.4 points, 3.2 rebounds and 1.3 assists per game.

On August 1, 2015, Brussino signed with Peñarol.^[5] In 2015–16, he averaged 14.6 points, 5.5 rebounds, 3.1 assists and 1.5 steals in 59 games.

On July 15, 2016, Brussino signed with the Dallas Mavericks.^[6] He made his NBA debut in the Mavericks' season opener on October 26, 2016, recording one assist in 34 seconds of game time in a 130–121 overtime loss to the Indiana Pacers.^[7] On March 15, 2017, he scored eight of his season-high 11 points in the fourth quarter of the Mavericks' 112–107 win over the Washington Wizards.^[8] He also had nine rebounds in the game while playing 23 minutes off the bench.^[9] On April 4, 2017, he had a season-high 13 points along with seven rebounds and five assists in a 98–87 loss to the Sacramento Kings.^[10] During his rookie season, he had multiple assignments with the Texas Legends of the NBA Development League.^[11] On July 20, 2017, he was waived by the Mavericks.^[12]

On July 22, 2017, Brussino was claimed off waivers by the Atlanta Hawks.^[13] On December 8, 2017, he was waived by the Hawks after appearing in four games. He also appeared in eight contests with the Erie BayHawks, Atlanta's NBA G League affiliate.^[14]

On 31 December 2017, Brussino signed with Spanish club Herbalife Gran Canaria for the rest of the 2017–18 season.^[15]

On July 26, 2018, Brussino signed a one–plus–one deal with Iberostar Tenerife of the Liga ACB.^[16]

On July 5, 2019, Brussino signed a two-year deal with Basket Zaragoza of the Liga ACB.^[17]

Brussino is a member of the senior Argentine national basketball team. With Argentina's senior national team, he won a silver medal at the 2015 FIBA Americas Championship. He also played at the 2016 Summer Olympic Games, and at the 2017 FIBA AmeriCup, where he won a silver medal, and was named to the All-Tournament Team.^[18]

In 2019, he took part in the team that won the Pan American gold medal in Lima. He was included in the Argentine squad for the 2019 FIBA Basketball World Cup and clinched silver medal with Argentina which emerged as runners-up to Spain at the 2019 FIBA Basketball World Cup.^[19]

Brussino's brother, Juan, also plays basketball in Argentina.^[20]