The Marikina–Infanta Highway, also known as the Marcos Highway or MARILAQUE Highway (MARILAQUE stands for Manila-Rizal-Laguna-Quezon), is a scenic mountain 110-kilometer highway that connects Metro Manila with Infanta, Quezon in the Philippines.

The highway starts in Marikina near Katipunan Avenue, the Loyola Heights segment of Circumferential Road 5, in Quezon City. It traverses the Marikina Valley and passes through Antipolo, where it intersects the Sumulong Highway (at Masinag). After Masinag the road starts its ascent towards the Sierra Madre passing through Tanay, Rizal, Santa Maria, Laguna, finally to Infanta, Quezon.

Marikina—Infanta Highway starts as a physical continuation of Aurora Boulevard under Katipunan Flyover. The highway slightly curves at the intersection with Andres Bonifacio Avenue connecting the Marikina city proper, then crosses the Marikina River. The Diosdado B. Macapagal Bridge that connects with C-5 merges in front of SM City Marikina. The Manila Line 2 and the Cainta - Marikina subtransmission line of Meralco parallel the highway. The highway makes another slight curve at the approach to Cainta. It soon runs over the Cainta-Marikina boundary, and then goes straight towards the Cainta-Antipolo boundary towards the Masinag Junction with Sumulong Highway wherein it continues on to Cogeo towards the rest of the Rizal Province.

This section, commonly called Marcos Highway, is a divided road featuring U-turn slots, and bike lanes. Several establishments, like the Riverbanks Center, SM City Marikina, Ayala Malls Feliz, Robinsons Metro East, Sta. Lucia East Grand Mall, and SM City Masinag are primary landmarks accessible through the road. Meralco subtransmission lines line the Cainta-Masinag segment of the highway.

This stretch of the highway is a standard 2-6 lane road divided by lane markings typical of national highways located in the provinces. Road size varies depending on the density of the location as well as the engineering district wherein numerous road widening may occur as determined by the DPWH. The road ends and merges with Famy–Real–Infanta Road (Route 601).

Since 2014 with the implementation of the new route numbering system by the Department of Public Works and Highways (DPWH), it is the component of National Route 59 (N59) of the Philippine highway network in the Greater Manila Area. From Rizal to Quezon, the road remains unnumbered and identified as a tertiary national road.

Marikina—Infanta Road existed far back to the American colonial era as Highway 55 and Manila-Infanta Highway, which included present-day Recto Avenue, Legarda Street, Magsaysay Boulevard and Aurora Boulevard.