Baseball

• Frank Rodriguez (born 1972), pitcher for the Minnesota Twins and Seattle Mariners

• Francisco Rodríguez (Venezuelan pitcher) (born 1982), relief pitcher who is nicknamed "K-Rod"

• Francisco Rodríguez (Mexican pitcher) (born 1983), Mexican League, Tigres de Quintana Roo

Boxing

• Francisco Rodríguez (boxer, born 1945), Venezuelan boxer

• Francisco Rodriguez (boxer, born 1984) (1984–2009), American boxer

• Francisco Rodríguez Jr. (born 1993), Mexican boxer

Cycling

• Francisco Rodríguez (cyclist, born 1906) (1906–?), Argentine cyclist

• Francisco Rodríguez (cyclist, born 1915) (1915–1998), Mexican cyclist

• Francisco Rodríguez Maldonado (born 1960), Colombian cyclist

Football

• Francisco Javier Rodríguez (born 1981), Mexican footballer

• Francisco Rodríguez García (born 1934), Spanish footballer

• Francisco Javier Rodríguez Vílchez (born 1978), Spanish footballer and manager

• Francisco Rodríguez Araya (born 1995), Swiss footballer

Other

• Francisco Rodríguez (economist), Venezuelan economist

• Francisco Rodríguez (Spanish judoka) (born 1957), Spanish Olympic judoka

• Francisco Rodríguez (Puerto Rican judoka) (born 1970), Puerto Rican Olympic judoka

• Francisco Rodríguez (President of Panama) (born 1938), provisional President of Panama in 1989

• Francisco Rodríguez (rower) (born 1953), Cuban Olympic rower

• Francisco Rodríguez Adrados (born 1922), Spanish Hellenist

• Francisco Rodríguez Barrientos (born 1956), Costa Rican writer and sociologist

• Francisco Rodríguez Pascual (1927–2007), Spanish humanist and anthropologist

• Francisco José Rodríguez (born 1980), Spanish volleyball player

See also

• Frank Rodriguez, rock organist with Question Mark & the Mysterians