Everipedia Logo
Everipedia is now IQ.wiki - Join the IQ Brainlist and our Discord for early access to editing on the new platform and to participate in the beta testing.
FM (chemotherapy)

FM (chemotherapy)

FM in the context of chemotherapy means a chemotherapy regimen used as first-line therapy in indolent lymphomas. In combination with rituximab it is called R-FM or RFM or FM-R or FMR.

The [R]-FM regimen consists of:

  1. **(R)**ituximab - an anti-CD20 monoclonal antibody that is able to kill both normal B cells and malignant ones;

  2. **(F)**ludarabine - an antimetabolite;

  3. **(M)**itoxantrone - a synthetic antracycline analogue (an antraquinone) that is able to intercalate DNA and prevent mitosis.[1]

This regimen is also sometimes used in some autoimmune disorders that are inherently sensitive to rituximab, fludarabine and mitoxantrone in monotherapies (e.g. multiple sclerosis).

Dosing regimen

DrugDoseModeDays
**(R)**ituximab375 mg/m2IV infusionDay 1
**(F)**ludarabine25 mg/m2IV infusionDays 1-3
**(M)**itoxantrone10 mg/m2IV infusionDay 1

References

[1]
Citation Linkjco.ascopubs.orgFludarabine Plus Mitoxantrone With and Without Rituximab Versus CHOP With and Without Rituximab As Front-Line Treatment for Patients With Follicular Lymphoma
Sep 20, 2019, 7:22 AM
[2]
Citation Linkjco.ascopubs.orgFludarabine Plus Mitoxantrone With and Without Rituximab Versus CHOP With and Without Rituximab As Front-Line Treatment for Patients With Follicular Lymphoma
Sep 20, 2019, 7:22 AM
[3]
Citation Linken.wikipedia.orgThe original version of this page is from Wikipedia, you can edit the page right here on Everipedia.Text is available under the Creative Commons Attribution-ShareAlike License.Additional terms may apply.See everipedia.org/everipedia-termsfor further details.Images/media credited individually (click the icon for details).
Sep 20, 2019, 7:22 AM