3,4-Ethylenedioxy- N -methylamphetamine ( EDMA ) is an entactogen drug of the amphetamine class. [2] [5] It is an analogue of MDMA where the methylenedioxy ring has been replaced by an ethylenedioxy ring. [2] [5] EDMA was first synthesised by Alexander Shulgin. [2] In his book PiHKAL , the dosage is listed as 150–250 mg, and the duration listed as 3–5 hours. [2] According to Shulgin, EDMA produces a bare threshold consisting of paresthesia, nystagmus, and hypnogogic imagery, with few to no additional effects. [2] Scientific research has demonstrated that EDMA acts as a non- neurotoxic serotonin releasing agent with moderately diminished potency relative to MDMA, and with negligible effects on dopamine release. [5] Based on Shulgin's reports of essential inactivity at 150–250 mg, it might be more active at higher doses.