According to IAFD, one of her first appearances was in Dirty Debutantes , Vol. 37, with Ed Powers. In that video, she says she came up with the name Anna Malle on her own as a play on the word "animal" to describe her sexual style.
She performed in over 360 films, frequently with her husband Hank Armstrong  as co-star. Of those films, she has a directorial credit in five of them in addition to performing in them. While Malle performed a variety of scenes, her most popular scenes involved lesbianism and anal sex. Videos based on archival footage are still being released after her death. 
Malle was killed in a car accident near Las Vegas, Nevada, on January 25, 2006.