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(acyl-carrier-protein) phosphodiesterase

(acyl-carrier-protein) phosphodiesterase

In enzymology, a [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14 [21] ) is an enzyme that catalyzes the chemical reaction

holo-[acyl-carrier-protein] + H2O4'-phosphopantetheine + apo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[holo-[acyl-carrier-protein]]] and H2O, whereas its two products are 4'-phosphopantetheine and [[apo-[acyl-carrier-protein]]].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

[acyl-carrier-protein] phosphodiesterase
Identifiers
EC number3.1.4.14 [5]
CAS number37288-21-4 [6]
Databases
IntEnzIntEnz view [7]
BRENDABRENDA entry [8]
ExPASyNiceZyme view [9]
KEGGKEGG entry [10]
MetaCycmetabolic pathway [11]
PRIAMprofile [12]
PDB structuresRCSB PDB [13] PDBe [14] PDBsum [15]
Gene OntologyAmiGO [16] / QuickGO [17]
Search
PMCarticles [18]
PubMedarticles [19]
NCBIproteins [20]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B [22] and 1TIK [23] .

References

[1]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/224058224058
Sep 24, 2019, 3:30 AM
[2]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/42904424290442
Sep 24, 2019, 3:30 AM
[3]
Citation Link//doi.org/10.1074%2Fjbc.M50573620010.1074/jbc.M505736200
Sep 24, 2019, 3:30 AM
[4]
Citation Link//www.ncbi.nlm.nih.gov/pubmed/1610732916107329
Sep 24, 2019, 3:30 AM
[5]
Citation Linkwww.qmul.ac.uk3.1.4.14
Sep 24, 2019, 3:30 AM
[6]
Citation Linkwww.commonchemistry.org37288-21-4
Sep 24, 2019, 3:30 AM
[7]
Citation Linkwww.ebi.ac.ukIntEnz view
Sep 24, 2019, 3:30 AM
[8]
Citation Linkwww.brenda-enzymes.orgBRENDA entry
Sep 24, 2019, 3:30 AM
[9]
Citation Linkwww.expasy.orgNiceZyme view
Sep 24, 2019, 3:30 AM
[10]
Citation Linkwww.genome.jpKEGG entry
Sep 24, 2019, 3:30 AM
[11]
Citation Linkbiocyc.orgmetabolic pathway
Sep 24, 2019, 3:30 AM
[12]
Citation Linkpriam.prabi.frprofile
Sep 24, 2019, 3:30 AM
[13]
Citation Linkwww.rcsb.orgRCSB PDB
Sep 24, 2019, 3:30 AM
[14]
Citation Linkwww.ebi.ac.ukPDBe
Sep 24, 2019, 3:30 AM
[15]
Citation Linkwww.ebi.ac.ukPDBsum
Sep 24, 2019, 3:30 AM
[16]
Citation Linkamigo.geneontology.orgAmiGO
Sep 24, 2019, 3:30 AM
[17]
Citation Linkwww.ebi.ac.ukQuickGO
Sep 24, 2019, 3:30 AM
[18]
Citation Linkwww.ncbi.nlm.nih.govarticles
Sep 24, 2019, 3:30 AM
[19]
Citation Linkwww.ncbi.nlm.nih.govarticles
Sep 24, 2019, 3:30 AM
[20]
Citation Linkwww.ncbi.nlm.nih.govproteins
Sep 24, 2019, 3:30 AM