Garfinkle completed her undergraduate studies at University of California, Berkeley, receiving a B.S.E. in bioengineering.  She went on to attend The Wharton School of the University of Pennsylvania, where she received her Master of Business Administration.  
She founded Arboretum Ventures in 2002 and is a Managing Director. Garfinkle leads the fund-raising effort at Arboretum and has raised over $450 million over four funds. At Arboretum, Jan’s investments focus on promising medical technologies that enable meaningful healthcare system savings. 
Jan has led more than a dozen investments and currently serves on the Board of Directors for NxThera, Cereve, NeuMoDx, Cardiac Dimensions and Strata Oncology. Jan’s past investments have led to successful exits creating over $2 billion in enterprise value.