Anastasia Karanikolaou was born and raised in California and is of Greek descent. She grew up with one older sister, Alexia; Anastasia has a tattoo of a heart and Alexia's birthday in Roman numerals on her right arm.
Karanikolaou's close proximity to the Kardashian family has helped her garner fame in her own right. On Instagram, she has over 2.1 million followers and on Twitter boasts 189k followers as of November 2016.  She has begun a career in modeling.
In January 2017, Anastasia Karanikolaou had breast surgery; she was 19 years old at the time. She did for work purposes, as she was not able to fit into certain items of clothing on photo shoots. After a consultation, Karanikolaou and her doctor - Ashkan Ghavami - decided to do a breast lift without implants to help regain symmetry and leave the most natural effect.