Gray was a regular panellist on Graham Kennedy's Blankety Blanks in 1977-1978. He had earlier taken a straight dramatic role as publican Bunny Howard in the early episodes of soap opera The Young Doctors in 1976. He left his role in The Young Doctors after his initial 13-week contract expired in order to work on Blankety Blanks. Kennedy himself had convinced Gray to do Blankety Blanks Gray had been receiving $100 a day for The Young Doctors, with Blankety Blanks paying $45 an episode this represented a pay cut. Later Gray signed with agent Harry M Miller who negotiated the increased pay rate of $75 per episode of Blankety Blanks which remained until the series ended.
Gray hosted an Australian version of the American game show Beat The Clock called Free for All in 1973.
Gray later hosted the celebrity game show Celebrity Tattle Tales from 1979-1980, and Play Your Cards Right from 1984-1985.
According to Gray's autobiography It's Funny Being Ugly, on 31 May 2005 Gray was not invited to speak at Kennedy's funeral, and did not know where the funeral was to be held. He had to call presenter Philip Brady for details.
On 19 October 2011, Gray appeared in a comedy sketch for the ABC1 show Hamster Wheel.
In the 2000s Gray endorsed an erectile dysfunction nasal spray.
Ugly Dave Gray has two children, a daughter and a son. His son, also called Dave Gray, is following in his father's footsteps as a comedian.
In 2011 Gray announced that he wished to be cryogenically frozen after death.