Smith signed with the Indianapolis Colts as an undrafted free agent on May 2, 2016. He was released on September 3, 2016 and was signed to the practice squad the next day. He was elevated to the active roster on October 18, 2016. He was released by the Colts on November 8, 2016 and was signed to the practice squad the next day. He signed a reserve/future contract with the Colts on January 2, 2017.
On August 9, 2017, Smith was waived/injured by the Colts and placed on injured reserve. He was released on August 16, 2017.