The gallery was opened in December 2001 by Anahita Ghabaian Etehadieh with the collaboration of Minou Saberi (1938–2010). It has had an active role in the development of the new artistic movement in Iranian photography of the past decade by providing a sort of laboratory in which new ideas and methods are discussed, shaped, and formed. Many famed Iranian Photographers such as the late Bahman Jalali and Shadi Ghadirian have collaborated with the gallery while a younger generation have sprung up.
Silk Road Gallery has had a fair deal of success in presenting Iranian photographers to the international audience by participating in various fairs and exhibitions such as Paris Photo (2001, 2010, 2009, 2004), Arco (2009 and 2007), Art Dubai (2009 and 2008), Art Abu Dhabi/Art Paris Abu Dhabi (2010, 2008, 2007), and Photoquai (2007 and 2009).
The tenth anniversary of the gallery was marked by the publication of a book in French, on contemporary Iranian Photography called "La photographie iranienne, Un Regard sur la creation contemporaine en Iran".