When house music began in the 1980s editor and DJ Dave Seaman turned the magazine from a newsletter for DJs to a magazine covering all dance music and club culture. Mixmag, in association with its original publishing company, DMC Publishing, released a series of CDs under the "Mixmag Live" heading.
The magazine, which reached a circulation of up to 70,000 copies during the height of the popularity of acid house, was later sold to EMAP Ltd. in the mid-1990s. After a dip in sales in 2003, it was then bought by Development Hell, the company that also owned The Word music magazine, in 2005. In 2007, Nick DeCosemo became editor.
In 2001, the magazine teamed up with Virgin Records to release a double album titled B!g Tunes.