Leonardo di ser Piero da Vinci   ( Italian: [leoˈnardo di ˌsɛr ˈpjɛːro da (v)ˈvintʃi] ( ) ; 15 April 1452 – 2 May 1519), more commonly Leonardo da Vinci or simply Leonardo , was an Italian Renaissance polymath whose areas of interest included invention , painting , sculpting , architecture , science , music , mathematics , engineering , literature , anatomy , geology , astronomy , botany , writing , history , and cartography . He has been variously called the father of palaeontology , ichnology , and architecture, and is widely considered one of the greatest painters of all time. Sometimes credited with the inventions of the parachute , helicopter and tank ,   he epitomised the Renaissance humanist ideal.
Many historians and scholars regard Leonardo as the prime exemplar of the " Universal Genius " or "Renaissance Man", an individual of "unquenchable curiosity" and "feverishly inventive imagination", and he is widely considered one of the most diversely talented individuals ever to have lived. According to art historian Helen Gardner , the scope and depth of his interests were without precedent in recorded history, and "his mind and personality seem to us superhuman, while the man himself mysterious and remote". Marco Rosci notes that while there is much speculation regarding his life and personality, his view of the world was logical rather than mysterious, and that the empirical methods he employed were unorthodox for his time.
Born out of wedlock to a notary , Piero da Vinci, and a peasant woman, Caterina, in Vinci in the region of Florence , Leonardo was educated in the studio of the renowned Florentine painter Andrea del Verrocchio . Much of his earlier working life was spent in the service of Ludovico il Moro in Milan. He later worked in Rome, Bologna and Venice , and he spent his last years in France at the home awarded to him by Francis I of France .
Leonardo was, and is, renowned primarily as a painter. Among his works, the Mona Lisa is the most famous and most parodied portrait  and The Last Supper the most reproduced religious painting of all time. Leonardo's drawing of the Vitruvian Man is also regarded as a cultural icon ,  being reproduced on items as varied as the euro coin, textbooks, and T-shirts.
A painting by Leonardo, Salvator Mundi , sold for a world record $450.3 million at a Christie's auction in New York, 15 November 2017, the highest price ever paid for a work of art.  Perhaps fifteen of his paintings have survived. Nevertheless, these few works, together with his notebooks, which contain drawings, scientific diagrams, and his thoughts on the nature of painting, compose a contribution to later generations of artists rivalled only by that of his contemporary, Michelangelo .
Leonardo is revered for his technological ingenuity . He conceptualised flying machines, a type of armoured fighting vehicle , concentrated solar power , an adding machine ,  and the double hull . Relatively few of his designs were constructed or even feasible during his lifetime, as the modern scientific approaches to metallurgy and engineering were only in their infancy during the Renaissance. Some of his smaller inventions, however, such as an automated bobbin winder and a machine for testing the tensile strength of wire, entered the world of manufacturing unheralded. A number of Leonardo's most practical inventions are nowadays displayed as working models at the Museum of Vinci. He made substantial discoveries in anatomy, civil engineering, geology, optics , and hydrodynamics , but he did not publish his findings and they had no direct influence on later science.
Leonardo was born on 15 April 1452 (Old Style) "at the third hour of the night" in the Tuscan hill town of Vinci , in the lower valley of the Arno river in the territory of the Medici -ruled Republic of Florence . He was the out-of-wedlock son of the wealthy Messer Piero Fruosino di Antonio da Vinci, a Florentine legal notary , and Caterina, a peasant. Leonardo had no surname in the modern sense – "da Vinci" simply meaning "of Vinci"; his full birth name was "Lionardo di ser Piero da Vinci", meaning "Leonardo, (son) of (Mes)ser Piero from Vinci". The inclusion of the title "ser" indicated that Leonardo's father was a gentleman.
Little is known about Leonardo's early life. He spent his first five years in the hamlet of Anchiano in the home of his mother, and from 1457 lived in the household of his father, grandparents and uncle in the small town of Vinci. His father had married a sixteen-year-old girl named Albiera Amadori, who loved Leonardo but died young in 1465 without children. When Leonardo was sixteen (1468), his father married again to twenty-year-old Francesca Lanfredini, who also died without children. Piero's legitimate heirs were born from his third wife Margherita di Guglielmo (who gave birth to six children:  Antonio, Giulian, Maddalena, Lorenzo, Violante and Domenico) and his fourth and final wife, Lucrezia Cortigiani (who bore him another six children:  Margherita, Benedetto, Pandolfo, Guglielmo, Bartolomeo and Giovanni).
In all, Leonardo had twelve half-siblings, who were much younger than him (the last was born when Leonardo was forty years old) and with whom he had very few contacts, but they caused him difficulty after his father's death in the dispute over the inheritance.
Leonardo received an informal education in Latin, geometry and mathematics. In later life, Leonardo recorded only two childhood incidents. One, which he regarded as an omen, was when a kite dropped from the sky and hovered over his cradle, its tail feathers brushing his face. The second occurred while he was exploring in the mountains: he discovered a cave and was both terrified that some great monster might lurk there and driven by curiosity to find out what was inside.
Leonardo's early life has been the subject of historical conjecture. Vasari , the 16th-century biographer of Renaissance painters, tells a story of Leonardo as a very young man: A local peasant made himself a round shield and requested that Ser Piero have it painted for him. Leonardo responded with a painting of a monster spitting fire that was so terrifying that Ser Piero sold it to a Florentine art dealer, who sold it to the Duke of Milan . Meanwhile, having made a profit, Ser Piero bought a shield decorated with a heart pierced by an arrow, which he gave to the peasant.
Verrocchio's workshop, 1466–76
In 1466, at the age of fourteen, Leonardo was apprenticed to the artist Andrea di Cione, known as Verrocchio , whose bottega (workshop) was "one of the finest in Florence". He apprenticed as a garzone (studio boy) to Andrea del Verrocchio, the leading Florentine painter and sculptor of his day (and would do so for 7 years).  Other famous painters apprenticed or associated with the workshop include Domenico Ghirlandaio , Perugino , Botticelli , and Lorenzo di Credi . Leonardo would have been exposed to both theoretical training and a vast range of technical skills, including drafting, chemistry, metallurgy, metal working, plaster casting, leather working, mechanics and carpentry as well as the artistic skills of drawing, painting, sculpting and modelling.
Much of the painted production of Verrocchio's workshop was done by his employees. According to Vasari, Leonardo collaborated with Verrocchio on his The Baptism of Christ , painting the young angel holding Jesus' robe in a manner that was so far superior to his master's that Verrocchio put down his brush and never painted again, although this is believed to be apocryphal. Close examination reveals areas that have been painted or touched-up over the tempera using the new technique of oil paint ; the landscape, the rocks seen through the brown mountain stream and much of the figure of Jesus bearing witness to the hand of Leonardo. Leonardo may have been the model for two works by Verrocchio: the bronze statue of David in the Bargello and the Archangel Raphael in Tobias and the Angel .
By 1472, at the age of twenty, Leonardo qualified as a master in the Guild of Saint Luke , the guild of artists and doctors of medicine, but even after his father set him up in his own workshop, his attachment to Verrocchio was such that he continued to collaborate with him. Leonardo's earliest known dated work is a drawing in pen and ink of the Arno valley, drawn on 5 August 1473.
Professional life, 1476–1513
Florentine court records of 1476 show that Leonardo and three other young men were charged with sodomy but acquitted; homosexual acts were illegal in Renaissance Florence. From that date until 1478 there is no record of his work or even of his whereabouts. In 1478, he left Verrocchio's studio and was no longer a resident at his father's house. One writer, called the Anonimo Gaddiano , claims that in 1480 Leonardo was living with the Medici and working in the Garden of the Piazza San Marco in Florence, a Neo-Platonic academy of artists, poets and philosophers that the Medici had established. In January 1478, he received an independent commission to paint an altarpiece for the Chapel of St. Bernard in the Palazzo Vecchio ; in March 1481, he received a second independent commission for The Adoration of the Magi for the monks of San Donato a Scopeto. Neither commission was completed, the second being interrupted when Leonardo went to Milan.
In 1482, Leonardo, who according to Vasari was a talented musician, created a silver lyre in the shape of a horse's head. Lorenzo de' Medici sent Leonardo to Milan, bearing the lyre as a gift, to secure peace with Ludovico Sforza , Duke of Milan . At this time Leonardo wrote an often-quoted letter describing the many marvellous and diverse things that he could achieve in the field of engineering and informing Ludovico that he could also paint. 
Leonardo worked in Milan from 1482 until 1499. He was commissioned to paint the Virgin of the Rocks for the Confraternity of the Immaculate Conception and The Last Supper for the monastery of Santa Maria delle Grazie . In the spring of 1485, Leonardo travelled to Hungary on behalf of Ludovico to meet Matthias Corvinus , for whom he is believed to have painted a Holy Family . Between 1493 and 1495, Leonardo listed a woman called Caterina among his dependents in his taxation documents. When she died in 1495, the list of funeral expenditures suggests that she was his mother.
Leonardo was employed on many different projects for Ludovico, including the preparation of floats and pageants for special occasions, designs for a dome for Milan Cathedral and a model for a huge equestrian monument to Francesco Sforza , Ludovico's predecessor. Seventy tons of bronze were set aside for casting it. The monument remained unfinished for several years, which was not unusual for Leonardo. In 1492, the clay model of the horse was completed. It surpassed in size the only two large equestrian statues of the Renaissance, Donatello's Gattamelata in Padua and Verrocchio's Bartolomeo Colleoni in Venice, and became known as the " Gran Cavallo ". Leonardo began making detailed plans for its casting; however, Michelangelo insulted Leonardo by implying that he was unable to cast it. In November 1494, Ludovico gave the bronze to be used for cannon to defend the city from invasion by Charles VIII .
At the start of the Second Italian War in 1499, the invading French troops used the life-size clay model for the Gran Cavallo for target practice. With Ludovico Sforza overthrown, Leonardo, with his assistant Salai and friend, the mathematician Luca Pacioli , fled Milan for Venice , where he was employed as a military architect and engineer, devising methods to defend the city from naval attack. On his return to Florence in 1500, he and his household were guests of the Servite monks at the monastery of Santissima Annunziata and were provided with a workshop where, according to Vasari, Leonardo created the cartoon of The Virgin and Child with St Anne and St John the Baptist , a work that won such admiration that "men and women, young and old" flocked to see it "as if they were attending a great festival".
In Cesena in 1502, Leonardo entered the service of Cesare Borgia , the son of Pope Alexander VI , acting as a military architect and engineer and travelling throughout Italy with his patron. Leonardo created a map of Cesare Borgia's stronghold, a town plan of Imola in order to win his patronage. Maps were extremely rare at the time and it would have seemed like a new concept. Upon seeing it, Cesare hired Leonardo as his chief military engineer and architect. Later in the year, Leonardo produced another map for his patron, one of Chiana Valley , Tuscany, so as to give his patron a better overlay of the land and greater strategic position. He created this map in conjunction with his other project of constructing a dam from the sea to Florence, in order to allow a supply of water to sustain the canal during all seasons.
Leonardo returned to Florence, where he rejoined the Guild of Saint Luke on 18 October 1503. He spent two years designing and painting a mural of The Battle of Anghiari for the Signoria, with Michelangelo designing its companion piece, The Battle of Cascina . In Florence in 1504, he was part of a committee formed to relocate, against the artist's will, Michelangelo's statue of David .
In 1506 Leonardo returned to Milan. Many of his most prominent pupils or followers in painting either knew or worked with him in Milan, including Bernardino Luini , Giovanni Antonio Boltraffio and Marco d'Oggiono . At this time he may have commenced a project for an equestrian figure of Charles II d'Amboise , the acting French governor of Milan. A wax model survives and, if genuine, is the only extant example of Leonardo's sculpture.
Leonardo did not stay in Milan for long because his father had died in 1504, and in 1507 he was back in Florence trying to sort out problems with his brothers over his father's estate. By 1508 Leonardo was back in Milan, living in his own house in Porta Orientale in the parish of Santa Babila.
Old age and death, 1513–1519
From September 1513 to 1516, under Pope Leo X , Leonardo spent much of his time living in the Belvedere in the Vatican in Rome, where Raphael and Michelangelo were both active at the time. In October 1515, King Francis I of France recaptured Milan. On 19 December, Leonardo was present at the meeting of Francis I and Pope Leo X, which took place in Bologna.  Leonardo was commissioned to make for Francis a mechanical lion that could walk forward then open its chest to reveal a cluster of lilies. In 1516, he entered Francis' service, being given the use of the manor house Clos Lucé , now a public museum, near the king's residence at the royal Château d'Amboise . He spent the last three years of his life here, accompanied by his friend and apprentice, Count Francesco Melzi , and supported by a pension totalling 10,000 scudi .
Leonardo died at Clos Lucé , on 2 May 1519 at the age of 67. The cause is generally stated to be recurrent stroke; this diagnosis is consistent with accounts of the state of Leonardo's alleged remains as described in 1863  Francis I had become a close friend. Vasari records that the king held Leonardo's head in his arms as he died, although this story, beloved by the French and portrayed in romantic paintings by Ingres , and other French artists, as well as by Angelica Kauffman , may be legend rather than fact. Vasari states that in his last days, Leonardo sent for a priest to make his confession and to receive the Holy Sacrament . In accordance with his will, sixty beggars followed his casket. Melzi was the principal heir and executor, receiving, as well as money, Leonardo's paintings, tools, library and personal effects. Leonardo also remembered his other long-time pupil and companion, Salai, and his servant Battista di Vilussis, who each received half of Leonardo's vineyards . His brothers received land, and his serving woman received a black cloak "of good stuff" with a fur edge.  Leonardo da Vinci was buried in the Chapel of Saint-Hubert in Château d'Amboise in France.
Some 20 years after Leonardo's death, Francis was reported by the goldsmith and sculptor Benvenuto Cellini as saying: "There had never been another man born in the world who knew as much as Leonardo, not so much about painting, sculpture and architecture, as that he was a very great philosopher." 
Location of remains
Leonardo's remains were originally interred in the chapel of Saint-Florentin at the Chateau d'Amboise in the Loire Valley. However, following the chapel's destruction in 1802, the whereabouts of Leonardo's remains became subject to dispute. While excavating the site in 1863 the poet Arsene Houssaye found a partially-complete skeleton and stone fragments bearing the inscription 'EO [...] DUS VINC'. The unusually large skull led Houssaye to conclude he had located the remains of Leonardo, which were re-interred in their present location of the chapel of Saint-Hubert, also at the Chateau d'Amboise.  Reflecting doubts about the attribution, a plaque above the tomb states that the remains are only "presumed" to be those of Leonardo. In 2016 it was announced that DNA tests were to be conducted to investigate the veracity of the attribution, with results expected in 2019. 
Relationships and influences
Florence: Leonardo's artistic and social background
Florence at the time of Leonardo's youth was the centre of Christian Humanist thought and culture. Leonardo commenced his apprenticeship with Verrocchio in 1466, the year that Verrocchio's master, the great sculptor Donatello , died. The painter Uccello , whose early experiments with perspective were to influence the development of landscape painting, was a very old man. The painters Piero della Francesca and Filippo Lippi , sculptor Luca della Robbia , and architect and writer Leon Battista Alberti were in their sixties. The successful artists of the next generation were Leonardo's teacher Verrocchio, Antonio del Pollaiuolo and the portrait sculptor Mino da Fiesole , whose lifelike busts give the most reliable likenesses of Lorenzo Medici's father Piero and uncle Giovanni.
Leonardo's youth was spent in a Florence that was ornamented by the works of these artists and by Donatello's contemporaries, Masaccio , whose figurative frescoes were imbued with realism and emotion, and Ghiberti , whose Gates of Paradise , gleaming with gold leaf , displayed the art of combining complex figure compositions with detailed architectural backgrounds. Piero della Francesca had made a detailed study of perspective,  and was the first painter to make a scientific study of light. These studies and Alberti's treatise De Pictura  were to have a profound effect on younger artists and in particular on Leonardo's own observations and artworks.
Massaccio's " Expulsion from the Garden of Eden " depicting the naked and distraught Adam and Eve created a powerfully expressive image of the human form, cast into three dimensions by the use of light and shade , which was to be developed in the works of Leonardo in a way that was to be influential in the course of painting. The humanist influence of Donatello's "David" can be seen in Leonardo's late paintings, particularly John the Baptist .
A prevalent tradition in Florence was the small altarpiece of the Virgin and Child . Many of these were created in tempera or glazed terracotta by the workshops of Filippo Lippi, Verrocchio and the prolific della Robbia family. Leonardo's early Madonnas such as The Madonna with a carnation and the Benois Madonna followed this tradition while showing idiosyncratic departures, particularly in the case of the Benois Madonna in which the Virgin is set at an oblique angle to the picture space with the Christ Child at the opposite angle. This compositional theme was to emerge in Leonardo's later paintings such as The Virgin and Child with St. Anne .
Leonardo was a contemporary of Botticelli , Domenico Ghirlandaio and Perugino , who were all slightly older than he was. He would have met them at the workshop of Verrocchio, with whom they had associations, and at the Academy of the Medici . Botticelli was a particular favourite of the Medici family, and thus his success as a painter was assured. Ghirlandaio and Perugino were both prolific and ran large workshops. They competently delivered commissions to well-satisfied patrons who appreciated Ghirlandaio's ability to portray the wealthy citizens of Florence within large religious frescoes, and Perugino's ability to deliver a multitude of saints and angels of unfailing sweetness and innocence.
These three were among those commissioned to paint the walls of the Sistine Chapel , the work commencing with Perugino's employment in 1479. Leonardo was not part of this prestigious commission. His first significant commission, The Adoration of the Magi for the Monks of Scopeto, was never completed.
In 1476, during the time of Leonardo's association with Verrocchio's workshop, the Portinari Altarpiece by Hugo van der Goes arrived in Florence, bringing from Northern Europe new painterly techniques that were to profoundly affect Leonardo, Ghirlandaio, Perugino and others. In 1479, the Sicilian painter Antonello da Messina , who worked exclusively in oils, travelled north on his way to Venice , where the leading painter Giovanni Bellini adopted the technique of oil painting, quickly making it the preferred method in Venice. Leonardo was also later to visit Venice.
Like the two contemporary architects Bramante and Antonio da Sangallo the Elder , Leonardo experimented with designs for centrally planned churches, a number of which appear in his journals, as both plans and views, although none was ever realised. 
Leonardo's political contemporaries were Lorenzo Medici (il Magnifico), who was three years older, and his younger brother Giuliano, who was slain in the Pazzi conspiracy in 1478. Leonardo was sent as an ambassador by the Medici court to Ludovico il Moro , who ruled Milan between 1479 and 1499.
With Alberti, Leonardo visited the home of the Medici and through them came to know the older Humanist philosophers of whom Marsiglio Ficino , proponent of Neo Platonism ; Cristoforo Landino , writer of commentaries on Classical writings, and John Argyropoulos , teacher of Greek and translator of Aristotle were the foremost. Also associated with the Academy of the Medici was Leonardo's contemporary, the brilliant young poet and philosopher Pico della Mirandola .  Leonardo later wrote in the margin of a journal, "The Medici made me and the Medici destroyed me." While it was through the action of Lorenzo that Leonardo received his employment at the court of Milan, it is not known exactly what Leonardo meant by this cryptic comment.
Although usually named together as the three giants of the High Renaissance , Leonardo, Michelangelo and Raphael were not of the same generation. Leonardo was twenty-three when Michelangelo was born and thirty-one when Raphael was born. Raphael lived until the age of only 37 and died in 1520, the year after Leonardo died, but Michelangelo went on creating for another 45 years.
Within Leonardo's lifetime, his extraordinary powers of invention, his "outstanding physical beauty", "infinite grace", "great strength and generosity", "regal spirit and tremendous breadth of mind", as described by Vasari,  as well as all other aspects of his life, attracted the curiosity of others. One such aspect was his respect for life, evidenced by his vegetarianism and his habit, according to Vasari, of purchasing caged birds and releasing them.  
Leonardo had many friends who are now renowned either in their fields or for their historical significance. They included the mathematician Luca Pacioli ,  with whom he collaborated on the book De divina proportione in the 1490s. Leonardo appears to have had no close relationships with women except for his friendship with Cecilia Gallerani and the two Este sisters, Beatrice and Isabella.  While on a journey that took him through Mantua , he drew a portrait of Isabella that appears to have been used to create a painted portrait, now lost.
Beyond friendship, Leonardo kept his private life secret. His sexuality has been the subject of satire, analysis, and speculation. This trend began in the mid-16th century and was revived in the 19th and 20th centuries, most notably by Sigmund Freud .  Leonardo's most intimate relationships were perhaps with his pupils Salai and Melzi. Melzi, writing to inform Leonardo's brothers of his death, described Leonardo's feelings for his pupils as both loving and passionate. It has been claimed since the 16th century that these relationships were of a sexual or erotic nature. Court records of 1476, when he was aged twenty-four, show that Leonardo and three other young men were charged with sodomy in an incident involving a well-known male prostitute. The charges were dismissed for lack of evidence, and there is speculation that since one of the accused, Lionardo de Tornabuoni, was related to Lorenzo de' Medici , the family exerted its influence to secure the dismissal.  Since that date much has been written about his presumed homosexuality and its role in his art, particularly in the androgyny and eroticism manifested in John the Baptist and Bacchus and more explicitly in a number of erotic drawings. 
Assistants and pupils
Gian Giacomo Caprotti da Oreno, nicknamed Salai or Il Salaino ("The Little Unclean One" i.e., the devil), entered Leonardo's household in 1490. After only a year, Leonardo made a list of his misdemeanours, calling him "a thief, a liar, stubborn, and a glutton", after he had made off with money and valuables on at least five occasions and spent a fortune on clothes.  Nevertheless, Leonardo treated him with great indulgence, and he remained in Leonardo's household for the next thirty years.  Salai executed a number of paintings under the name of Andrea Salai, but although Vasari claims that Leonardo "taught him a great deal about painting",  his work is generally considered to be of less artistic merit than others among Leonardo's pupils, such as Marco d'Oggiono and Boltraffio . In 1515, he painted a nude version of the Mona Lisa , known as Monna Vanna .  Salai owned the Mona Lisa at the time of his death in 1524, and in his will it was assessed at 505 lire, an exceptionally high valuation for a small panel portrait. 
In 1506, Leonardo took on another pupil, Count Francesco Melzi , the son of a Lombard aristocrat, who is considered to have been his favourite student. He travelled to France with Leonardo and remained with him until Leonardo's death. Melzi inherited the artistic and scientific works, manuscripts, and collections of Leonardo and administered the estate.
Despite the recent awareness and admiration of Leonardo as a scientist and inventor, for the better part of four hundred years his fame rested on his achievements as a painter. A handful of works that are either authenticated or attributed to him have been regarded as among the great masterpieces. These paintings are famous for a variety of qualities that have been much imitated by students and discussed at great length by connoisseurs and critics. By the 1490s Leonardo had already been described as a "Divine" painter.
Among the qualities that make Leonardo's work unique are his innovative techniques for laying on the paint; his detailed knowledge of anatomy, light, botany and geology; his interest in physiognomy and the way humans register emotion in expression and gesture; his innovative use of the human form in figurative composition; and his use of subtle gradation of tone. All these qualities come together in his most famous painted works, the Mona Lisa , the Last Supper , and the Virgin of the Rocks .
Leonardo first gained notoriety for his work on the Baptism of Christ , painted in conjunction with Verrocchio. Two other paintings appear to date from his time at Verrocchio's workshop, both of which are Annunciations . One is small, 59 centimetres (23 in) long and 14 centimetres (5.5 in) high. It is a "predella" to go at the base of a larger composition, a painting by Lorenzo di Credi from which it has become separated. The other is a much larger work, 217 centimetres (85 in) long. In both Annunciations, Leonardo used a formal arrangement, like two well-known pictures by Fra Angelico of the same subject, of the Virgin Mary sitting or kneeling to the right of the picture, approached from the left by an angel in profile, with a rich flowing garment, raised wings and bearing a lily. Although previously attributed to Ghirlandaio , the larger work is now generally attributed to Leonardo.
In the smaller painting, Mary averts her eyes and folds her hands in a gesture that symbolised submission to God's will. Mary is not submissive, however, in the larger piece. The girl, interrupted in her reading by this unexpected messenger, puts a finger in her bible to mark the place and raises her hand in a formal gesture of greeting or surprise. This calm young woman appears to accept her role as the Mother of God , not with resignation but with confidence. In this painting, the young Leonardo presents the humanist face of the Virgin Mary, recognising humanity's role in God's incarnation.
Paintings of the 1480s
In the 1480s, Leonardo received two very important commissions and commenced another work that was of ground-breaking importance in terms of composition. Two of the three were never finished, and the third took so long that it was subject to lengthy negotiations over completion and payment.
One of these paintings was St. Jerome in the Wilderness , which Bortolon associates with a difficult period of Leonardo's life, as evidenced in his diary: "I thought I was learning to live; I was only learning to die." Although the painting is barely begun, the composition can be seen and is very unusual. Jerome , as a penitent , occupies the middle of the picture, set on a slight diagonal and viewed somewhat from above. His kneeling form takes on a trapezoid shape, with one arm stretched to the outer edge of the painting and his gaze looking in the opposite direction. J. Wasserman points out the link between this painting and Leonardo's anatomical studies. Across the foreground sprawls his symbol, a great lion whose body and tail make a double spiral across the base of the picture space. The other remarkable feature is the sketchy landscape of craggy rocks against which the figure is silhouetted.
The daring display of figure composition, the landscape elements and personal drama also appear in the great unfinished masterpiece, the Adoration of the Magi , a commission from the Monks of San Donato a Scopeto. It is a complex composition, of about 250 x 250 centimetres. Leonardo did numerous drawings and preparatory studies, including a detailed one in linear perspective of the ruined classical architecture that forms part of the background. In 1482 Leonardo went to Milan at the behest of Lorenzo de' Medici in order to win favour with Ludovico il Moro , and the painting was abandoned.
The third important work of this period is the Virgin of the Rocks , commissioned in Milan for the Confraternity of the Immaculate Conception. The painting, to be done with the assistance of the de Predis brothers , was to fill a large complex altarpiece . Leonardo chose to paint an apocryphal moment of the infancy of Christ when the infant John the Baptist , in protection of an angel, met the Holy Family on the road to Egypt. The painting demonstrates an eerie beauty as the graceful figures kneel in adoration around the infant Christ in a wild landscape of tumbling rock and whirling water.  While the painting is quite large, about 200×120 centimetres , it is not nearly as complex as the painting ordered by the monks of St Donato, having only four figures rather than about fifty and a rocky landscape rather than architectural details. The painting was eventually finished; in fact, two versions of the painting were finished: one remained at the chapel of the Confraternity, while Leonardo took the other to France. The Brothers did not get their painting, however, nor the de Predis their payment, until the next century.
Paintings of the 1490s
Leonardo's most famous painting of the 1490s is The Last Supper , commissioned for the refectory of the Convent of Santa Maria della Grazie in Milan. It represents the last meal shared by Jesus with his disciples before his capture and death, and shows the moment when Jesus has just said "one of you will betray me", and the consternation that this statement caused.
The novelist Matteo Bandello observed Leonardo at work and wrote that some days he would paint from dawn till dusk without stopping to eat and then not paint for three or four days at a time. This was beyond the comprehension of the prior of the convent, who hounded him until Leonardo asked Ludovico to intervene. Vasari describes how Leonardo, troubled over his ability to adequately depict the faces of Christ and the traitor Judas, told the Duke that he might be obliged to use the prior as his model.
When finished, the painting was acclaimed as a masterpiece of design and characterisation, but it deteriorated rapidly, so that within a hundred years it was described by one viewer as "completely ruined". Leonardo, instead of using the reliable technique of fresco, had used tempera over a ground that was mainly gesso, resulting in a surface subject to mould and to flaking. Despite this, the painting remains one of the most reproduced works of art; countless copies have been made in every medium from carpets to cameos.
Paintings of the 16th century
Among the works created by Leonardo in the 16th century is the small portrait known as the Mona Lisa or "la Gioconda", the laughing one. In the present era it is arguably the most famous painting in the world. Its fame rests, in particular, on the elusive smile on the woman's face, its mysterious quality perhaps due to the subtly shadowed corners of the mouth and eyes such that the exact nature of the smile cannot be determined. The shadowy quality for which the work is renowned came to be called " sfumato ", or Leonardo's smoke. Vasari, who is generally thought to have known the painting only by repute, said that "the smile was so pleasing that it seemed divine rather than human; and those who saw it were amazed to find that it was as alive as the original".
Other characteristics of the painting are the unadorned dress, in which the eyes and hands have no competition from other details, the dramatic landscape background in which the world seems to be in a state of flux, the subdued colouring, and the extremely smooth nature of the painterly technique, employing oils laid on much like tempera and blended on the surface so that the brushstrokes are indistinguishable. Vasari expressed the opinion that the manner of painting would make even "the most confident master ... despair and lose heart." The perfect state of preservation and the fact that there is no sign of repair or overpainting is rare in a panel painting of this date.
In the painting Virgin and Child with St. Anne the composition again picks up the theme of figures in a landscape, which Wasserman describes as "breathtakingly beautiful" and harkens back to the St Jerome picture with the figure set at an oblique angle. What makes this painting unusual is that there are two obliquely set figures superimposed. Mary is seated on the knee of her mother, St Anne. She leans forward to restrain the Christ Child as he plays roughly with a lamb, the sign of his own impending sacrifice. This painting, which was copied many times, influenced Michelangelo, Raphael, and Andrea del Sarto , and through them Pontormo and Correggio . The trends in composition were adopted in particular by the Venetian painters Tintoretto and Veronese .
Leonardo's The Battle of Anghiara was a fresco commissioned in 1505 for the Salone dei Cinquecento (Hall of the Five Hundred) in the Palazzo Vecchio , Florence. Its central scene depicted four men riding raging war horses engaged in a battle for possession of a standard, at the Battle of Anghiari in 1440. At the same time his rival Michelangelo, who had just finished his David , was assigned the opposite wall. All that remains of Leonardo's work is a copy by Rubens , but Maurizio Seracini is convinced it can still be found and has spent a lifetime searching for it. He was allowed to drill some pilot holes in a mural in the Salone dei Cinquecento , Palazzo Vecchio , Florence , and his team did find evidence of an oil painting underneath. 
Leonardo was not a prolific painter, but he was a most prolific draftsman, keeping journals full of small sketches and detailed drawings recording all manner of things that took his attention. As well as the journals there exist many studies for paintings, some of which can be identified as preparatory to particular works such as The Adoration of the Magi , The Virgin of the Rocks and The Last Supper . His earliest dated drawing is a Landscape of the Arno Valley , 1473, which shows the river, the mountains, Montelupo Castle and the farmlands beyond it in great detail.
Among his famous drawings are the Vitruvian Man , a study of the proportions of the human body; the Head of an Angel , for The Virgin of the Rocks in the Louvre; a botanical study of Star of Bethlehem ; and a large drawing (160×100 cm) in black chalk on coloured paper of The Virgin and Child with St. Anne and St. John the Baptist in the National Gallery, London. This drawing employs the subtle sfumato technique of shading, in the manner of the Mona Lisa . It is thought that Leonardo never made a painting from it, the closest similarity being to The Virgin and Child with St. Anne in the Louvre.
Other drawings of interest include numerous studies generally referred to as "caricatures" because, although exaggerated, they appear to be based upon observation of live models. Vasari relates that if Leonardo saw a person with an interesting face he would follow them around all day observing them. There are numerous studies of beautiful young men, often associated with Salai, with the rare and much admired facial feature, the so-called "Grecian profile". These faces are often contrasted with that of a warrior. Salai is often depicted in fancy-dress costume. Leonardo is known to have designed sets for pageants with which these may be associated. Other, often meticulous, drawings show studies of drapery. A marked development in Leonardo's ability to draw drapery occurred in his early works. Another often-reproduced drawing is a macabre sketch that was done by Leonardo in Florence in 1479 showing the body of Bernardo Baroncelli, hanged in connection with the murder of Giuliano, brother of Lorenzo de' Medici, in the Pazzi conspiracy . With dispassionate integrity Leonardo has registered in neat mirror writing the colours of the robes that Baroncelli was wearing when he died.
Observation and invention
Journals and notes
Renaissance humanism recognised no mutually exclusive polarities between the sciences and the arts, and Leonardo's studies in science and engineering are sometimes considered as impressive and innovative as his artistic work. These studies were recorded in 13,000 pages of notes and drawings, which fuse art and natural philosophy (the forerunner of modern science). They were made and maintained daily throughout Leonardo's life and travels, as he made continual observations of the world around him.
Most of Leonardo's writings are in mirror-image cursive. While secrecy is often suggested as the reason for this style of writing, it may have been more of a practical expediency. Since Leonardo wrote with his left hand, it was probably easier for him to write from right to left.
Leonardo's notes and drawings display an enormous range of interests and preoccupations, some as mundane as lists of groceries and people who owed him money and some as intriguing as designs for wings and shoes for walking on water. There are compositions for paintings, studies of details and drapery, studies of faces and emotions, of animals, babies, dissections, plant studies, rock formations, whirlpools, war machines, flying machines and architecture.
These notebooks—originally loose papers of different types and sizes, distributed by friends after his death—have found their way into major collections such as the Royal Library at Windsor Castle , the Louvre , the Biblioteca Nacional de España , the Victoria and Albert Museum , the Biblioteca Ambrosiana in Milan, which holds the twelve-volume Codex Atlanticus , and British Library in London, which has put a selection from the Codex Arundel (BL Arundel MS 263) online.  The Codex Leicester is the only major scientific work of Leonardo in private hands; it is owned by Bill Gates and is displayed once a year in different cities around the world.
Leonardo's notes appear to have been intended for publication because many of the sheets have a form and order that would facilitate this. In many cases a single topic, for example, the heart or the human fetus, is covered in detail in both words and pictures on a single sheet. Why they were not published during Leonardo's lifetime is unknown.
Leonardo's approach to science was observational: he tried to understand a phenomenon by describing and depicting it in utmost detail and did not emphasise experiments or theoretical explanation. Since he lacked formal education in Latin and mathematics, contemporary scholars mostly ignored Leonardo the scientist, although he did teach himself Latin. In the 1490s he studied mathematics under Luca Pacioli and prepared a series of drawings of regular solids in a skeletal form to be engraved as plates for Pacioli's book De divina proportione , published in 1509.
The content of his journals suggest that he was planning a series of treatises to be published on a variety of subjects. A coherent treatise on anatomy was said to have been observed during a visit by Cardinal Louis 'D' Aragon's secretary in 1517. Aspects of his work on the studies of anatomy, light and the landscape were assembled for publication by his pupil Francesco Melzi and eventually published as Treatise on Painting by Leonardo da Vinci in France and Italy in 1651 and Germany in 1724, with engravings based upon drawings by the Classical painter Nicolas Poussin . According to Arasse, the treatise, which in France went into 62 editions in fifty years, caused Leonardo to be seen as "the precursor of French academic thought on art".
While Leonardo's experimentation followed clear scientific methods, a recent and exhaustive analysis of Leonardo as a scientist by Fritjof Capra argues that Leonardo was a fundamentally different kind of scientist from Galileo , Newton and other scientists who followed him in that, as a Renaissance Man, his theorising and hypothesising integrated the arts and particularly painting.
Anatomy and physiology
Leonardo started his study in the anatomy of the human body under the apprenticeship of Andrea del Verrocchio , who demanded that his students develop a deep knowledge of the subject.  As an artist, he quickly became master of topographic anatomy , drawing many studies of muscles , tendons and other visible anatomical features.
As a successful artist, Leonardo was given permission to dissect human corpses at the Hospital of Santa Maria Nuova in Florence and later at hospitals in Milan and Rome. From 1510 to 1511 he collaborated in his studies with the doctor Marcantonio della Torre . Leonardo made over 240 detailed drawings and wrote about 13,000 words towards a treatise on anatomy.  These papers were left to his heir, Francesco Melzi, for publication, a task of overwhelming difficulty because of its scope and Leonardo's idiosyncratic writing. The project was left incomplete at the time of Melzi's death more than 50 years later, with only a small amount of the material on anatomy included in Leonardo's Treatise on painting , published in France in 1632. During the time that Melzi was ordering the material into chapters for publication, they were examined by a number of anatomists and artists, including Vasari, Cellini and Albrecht Dürer , who made a number of drawings from them.
Leonardo's anatomical drawings include many studies of the human skeleton and its parts, and of muscles and sinews. He studied the mechanical functions of the skeleton and the muscular forces that are applied to it in a manner that prefigured the modern science of biomechanics .  He drew the heart and vascular system , the sex organs and other internal organs, making one of the first scientific drawings of a fetus in utero . The drawings and notation are far ahead of their time, and if published would undoubtedly have made a major contribution to medical science. 
Leonardo also closely observed and recorded the effects of age and of human emotion on the physiology, studying in particular the effects of rage. He drew many figures who had significant facial deformities or signs of illness. Leonardo also studied and drew the anatomy of many animals, dissecting cows, birds, monkeys, bears, and frogs, and comparing in his drawings their anatomical structure with that of humans. He also made a number of studies of horses.
Leonardo's dissections and documentation of muscles, nerves, and vessels helped to describe the physiology and mechanics of movement. He attempted to identify the source of 'emotions' and their expression. He found it difficult to incorporate the prevailing system and theories of bodily humours , but eventually he abandoned these physiological explanations of bodily functions. He made the observations that humours were not located in cerebral spaces or ventricles . He documented that the humours were not contained in the heart or the liver, and that it was the heart that defined the circulatory system. He was the first to define atherosclerosis and liver cirrhosis . He created models of the cerebral ventricles with the use of melted wax and constructed a glass aorta to observe the circulation of blood through the aortic valve by using water and grass seed to watch flow patterns. Vesalius published his work on anatomy and physiology in De humani corporis fabrica in 1543. 
Engineering and inventions
During his lifetime, Leonardo was valued as an engineer. In a letter to Ludovico il Moro , he wrote that he could create all sorts of machines both for the protection of a city and for siege. When he fled to Venice in 1499, he found employment as an engineer and devised a system of moveable barricades to protect the city from attack. He also had a scheme for diverting the flow of the Arno river, a project on which Niccolò Machiavelli also worked. Leonardo's journals include a vast number of inventions, both practical and impractical. They include musical instruments , a mechanical knight , hydraulic pumps, reversible crank mechanisms, finned mortar shells, and a steam cannon .
In 1502, Leonardo produced a drawing of a single span 720-foot (220 m) bridge as part of a civil engineering project for Ottoman Sultan Beyazid II of Constantinople . The bridge was intended to span an inlet at the mouth of the Bosporus known as the Golden Horn . Beyazid did not pursue the project because he believed that such a construction was impossible. Leonardo's vision was resurrected in 2001 when a smaller bridge based on his design was constructed in Norway.  
Leonardo was fascinated by the phenomenon of flight for much of his life, producing many studies, including Codex on the Flight of Birds ( c. 1505 ), as well as plans for several flying machines such as a flapping ornithopter and a machine with a helical rotor . The British television station Channel Four commissioned a 2003 documentary, Leonardo's Dream Machines , in which various designs by Leonardo, such as a parachute and a giant crossbow, were interpreted, constructed and tested.   Some of those designs proved successful, whilst others fared less well when practically tested.
Fame and reputation
Leonardo's fame within his own lifetime was such that the King of France carried him away like a trophy, and was claimed to have supported him in his old age and held him in his arms as he died.
Interest in Leonardo and his work has never diminished. Crowds still queue to see his best-known artworks, T-shirts still bear his most famous drawing, and writers continue to hail him as a genius while speculating about his private life, as well as about what one so intelligent actually believed in.
In the normal course of events many men and women are born with remarkable talents; but occasionally, in a way that transcends nature, a single person is marvellously endowed by Heaven with beauty, grace and talent in such abundance that he leaves other men far behind, all his actions seem inspired and indeed everything he does clearly comes from God rather than from human skill. Everyone acknowledged that this was true of Leonardo da Vinci, an artist of outstanding physical beauty, who displayed infinite grace in everything that he did and who cultivated his genius so brilliantly that all problems he studied he solved with ease.— Giorgio Vasari
The continued admiration that Leonardo commanded from painters, critics and historians is reflected in many other written tributes. Baldassare Castiglione , author of Il Cortegiano ("The Courtier"), wrote in 1528: "... Another of the greatest painters in this world looks down on this art in which he is unequalled ..." while the biographer known as "Anonimo Gaddiano" wrote, c. 1540 : "His genius was so rare and universal that it can be said that nature worked a miracle on his behalf ...".
The 19th century brought a particular admiration for Leonardo's genius, causing Henry Fuseli to write in 1801: "Such was the dawn of modern art, when Leonardo da Vinci broke forth with a splendour that distanced former excellence: made up of all the elements that constitute the essence of genius ..." This is echoed by A. E. Rio who wrote in 1861: "He towered above all other artists through the strength and the nobility of his talents."
By the 19th century, the scope of Leonardo's notebooks was known, as well as his paintings. Hippolyte Taine wrote in 1866: "There may not be in the world an example of another genius so universal, so incapable of fulfilment, so full of yearning for the infinite, so naturally refined, so far ahead of his own century and the following centuries." Art historian Bernard Berenson wrote in 1896: "Leonardo is the one artist of whom it may be said with perfect literalness: Nothing that he touched but turned into a thing of eternal beauty. Whether it be the cross section of a skull, the structure of a weed, or a study of muscles, he, with his feeling for line and for light and shade, forever transmuted it into life-communicating values."
The interest in Leonardo's genius has continued unabated; experts study and translate his writings, analyse his paintings using scientific techniques, argue over attributions and search for works which have been recorded but never found.  Liana Bortolon, writing in 1967, said: "Because of the multiplicity of interests that spurred him to pursue every field of knowledge ... Leonardo can be considered, quite rightly, to have been the universal genius par excellence, and with all the disquieting overtones inherent in that term. Man is as uncomfortable today, faced with a genius, as he was in the 16th century. Five centuries have passed, yet we still view Leonardo with awe."
A painting by Leonardo, Salvator Mundi , depicting Jesus Christ holding an orb sold for a world record $450.3 million at a Christie's auction in New York, 15 November 2017.  The highest price previously paid for a work of art at auction was for Pablo Picasso 's Les Femmes d'Alger , which sold for $179.4 million in May 2015 at Christie's New York. $300 million, for Willem de Kooning 's Interchange , sold privately in September 2015 by the David Geffen Foundation to hedge fund manager Kenneth C. Griffin, was formerly the highest known sale price for any artwork.