High school career
Uthoff committed to the University of Wisconsin, where he sat out the 2011–12 season as a redshirt. He played briefly in the 2012–13 season for the Badgers before abruptly deciding to transfer mid-season. His case received national press as Wisconsin coach Bo Ryan originally barred the player from transferring to 26 different schools. After heavy public scrutiny, Ryan reduced his restrictions to only cover the Big Ten Conference.  Uthoff ultimately chose Iowa, a Big Ten school, opting to pay his own way in the 2012–13 season as he sat out the year as a transfer per NCAA regulations. 
Uthoff finally took the court for the Hawkeyes in 2013–14 season as a redshirt sophomore. He was a key player off the bench for the team, averaging 7.6 points and 4.6 rebounds per game. With graduation losses the following season, he entered the starting lineup. As a junior, he averaged 12.4 points and 6.4 rebounds per game as a complement to senior forward Aaron White.  At the close of the year, Uthoff was named third-team All-Big Ten. 
Leading up to his senior season, Uthoff was named to the preseason All-Big Ten team.  With the departure of Aaron White, Uthoff stepped into the role of the Hawkeyes' top scoring option.  He was named to the 35-man midseason watchlist for the Naismith Trophy on February 11.  Over his three-year career, he averaged 13.0 points, 5.8 rebounds and 1.7 blocks in 100 games. He finished his collegiate career ranked 19th all-time in Hawkeyes scoring (1,298 points), fourth in blocked shots (177) and 10th in three-pointers made (137).
NBA D-League (2016–2017)
After going undrafted in the 2016 NBA draft, Uthoff joined the Sacramento Kings for the 2016 NBA Summer League.  On August 2, 2016, he signed with the Toronto Raptors,  but was waived on October 22 after appearing in one preseason game.  On October 30, he was acquired by Raptors 905 of the NBA Development League as an affiliate player of the Raptors.  On January 27, 2017, he was traded to the Fort Wayne Mad Ants. 
Dallas Mavericks (2017)
On March 9, 2017, Uthoff signed a 10-day contract with the Dallas Mavericks.   He made his NBA debut the following day in the Mavericks' 105–96 win over the Brooklyn Nets, playing two minutes off the bench.  On March 19, 2017, he signed a second 10-day contract with the Mavericks.  During his first 20 days as a Maverick, he received two assignments to the Texas Legends.  On March 29, 2017, he signed a multi-year contract with the Mavericks. 
NBA career statistics
|GP||Games played||GS||Games started||MPG||Minutes per game|
|FG%||Field goal percentage||3P%||3-point field goal percentage||FT%||Free throw percentage|
|RPG||Rebounds per game||APG||Assists per game||SPG||Steals per game|
|BPG||Blocks per game||PPG||Points per game||Bold||Career high|
The son of Dale and Diane Uthoff, he has an older brother, Dale, and three older sisters, Erika, Jenna and Valerie. He majored in Economics.  Uthoff's third cousin Dean Uthoff played at Iowa State and then professionally in Australia's National Basketball League for 13 years.