Headquartered in Washington, D.C., the organization was founded in July 2014 by Perianne Boring. In October 2014, the chamber received 501(c)(6) non-profit status from the Internal Revenue Service. In 2015, economist and former JPMorgan Chase executive Blythe Masters was appointed to the advisory board.
In 2017, internet pioneer and Transmission Control Protocol (TCP) inventor Bob Kahn keynoted the DC Blockchain Summit at Georgetown University. Beginning in 2017, several multinational corporations and international financial services holding companies announced their intentions to join the Chamber of Digital Commerce including BNY Mellon, BNP Paribas, Accenture, IHS Markit, Cisco, and Intuit.In October 2017, Chamber Of Digital Commerce along with U.S. Department Of Commerce lead The First Blockchain Certified Trade Mission To The United Arab Emirates.
In August 2014, political news site The Hill reported that the Chamber had registered a political action committee with the United States Federal Election Commission. As The Hill piece noted, “formation of the PAC is a sign of increasing maturity for Bitcoin and a signal that politicians could face political pressure to support virtual currencies.”     To date, however, the PAC has only raised $10,000 of which only $2,700 have been contributed to a candidate.