Barbel may refer to:
- Barbel (anatomy), a whisker-like organ near the mouth found in some fish (notably catfish, loaches and cyprinids) and turtles.
- Barbel (fish), a common name for certain species of fish.
- USS Barbel (SS-316), a US Navy submarine launched in 1943.
- USS Barbel (SS-580), a US Navy submarine launched in 1958.
- The Barbel class of submarines of which SS-580 was the lead ship.
- Barbell - weight training equipment.