Roger Federer was the three-time defending champion. He won his 4th straight US Open title beating first-time Grand Slam finalist Novak Djokovic in the final 7–6(7–4), 7–6(7–2), 6–4. It was Federer's 12th major title overall and his third out of three years in which he won three of the four majors in a single calendar season.[207]

Seeds

Qualifying draw

Draw

Key

Finals

QuarterfinalsSemifinalsFinals
                     
1 Roger Federer77776  
5 Andy Roddick65642  
1 Roger Federer767  
4 Nikolay Davydenko515  
4 Nikolay Davydenko666  
10 Tommy Haas334  
1 Roger Federer77776  
3 Novak Djokovic64624  
17 Carlos Moyà4671  
3 Novak Djokovic6796  
3 Novak Djokovic666  
15 David Ferrer443  
20 Juan Ignacio Chela235  
15 David Ferrer667  

Top half

Section 1

First RoundSecond RoundThird RoundFourth Round
1 R Federer666  
Q S Jenkins324  1 R Federer666  
Q R Schüttler737743Q P Capdeville144  
Q P Capdeville5664661 R Federer64666 
Q T Ascione20r  WC J Isner77242 
Q R de Voest63   Q R de Voest3364  
WC J Isner6477776 WC J Isner6677  
26 J Nieminen7764654 1 R Federer3666 
21 JC Ferrero344    F López6414 
  F López666    F López6373677
  R Kendrick6434    I Andreev7756465
  I Andreev7766    F López36777 
WC D Young62666 WC D Young63655 
  C Guccione77323 WC D Youngw/o    
  S Roitman512  13 R Gasquet     
13 R Gasquet766  

Section 2

First RoundSecond RoundThird RoundFourth Round
9 T Berdych6776  
  M Gicquel3602  9 T Berdych766  
  S Bolelli6636   S Bolelli533  
  J Benneteau3461 9 T Berdych77677  
  G Simon66     F Verdasco62163  
Q A Waske41r    G Simon043  
  F Verdasco31666  F Verdasco666  
22 P-H Mathieu664339 T Berdych660r  
32 I Karlović65467845 A Roddick782   
  A Clément7764666  A Clément46471161 
  T Johansson27766   T Johansson6776977 
  N Massú66333   T Johansson320  
  J Acasuso66266 5 A Roddick666  
  M Vassallo47734   J Acasuso612r 
  J Gimelstob6633  5 A Roddick466  
5 A Roddick7866  

Section 3

First RoundSecond RoundThird RoundFourth Round
4 N Davydenko666  
WC J Levine401  4 N Davydenko666  
  N Kiefer6776    N Kiefer222  
  V Spadea2613  4 N Davydenko767  
  P Luczak64366  28 N Almagro505  
  L Horna77678    L Horna421r 
WC A Kuznetsov4064  28 N Almagro662  
28 N Almagro6677  4 N Davydenko666  
19 A Murray666    H-t Lee134  
Q P Cuevas230  19 A Murray56646
  JP Guzmán3642    J Björkman73161
  J Björkman6776  19 A Murray3365 
  D Hrbatý7745784  H-t Lee6627 
  H-t Lee6467666  H-t Lee776  
  R Ramírez Hidalgo3653 14 G Cañas553  
14 G Cañas6476 

Section 4

First RoundSecond RoundThird RoundFourth Round
10 T Haas65766 
Q S Darcis77534 10 T Haas4667 
  B Becker66441Q P Petzschner6325 
Q P Petzschner2366610 T Haas66346
  P Goldstein11r    S Grosjean24663
  S Grosjean64     S Grosjean66666 
  M Mirnyi67378   M Mirnyi47843 
18 M Baghdatis35666 10 T Haas463677
29 F Volandri3644 6 J Blake646064
  M Llodra6466   M Llodra133  
  S Koubek7766    S Koubek666  
  S Querrey6111    S Koubek46651 
  F Santoro66866 6 J Blake63776 
  A Montañés171021   F Santoro46264
  M Russell66364  6 J Blake63646
6 J Blake78677  

Bottom half

Section 5

First RoundSecond RoundThird RoundFourth Round
8 T Robredo6776  
LL B Reynolds3651  8 T Robredo636676
  M Fish666    M Fish464794
Q B Echagaray412  8 T Robredo132  
Q M Przysiężny16164   E Gulbis666  
  M Berrer64677   M Berrer6421  
  E Gulbis7776    E Gulbis7766  
30 P Starace5643    E Gulbis52774 
17 C Moyá666  17 C Moyá76656 
Q B Phau124  17 C Moyá667  
  G García-López63565  I Kunitsyn4453  
  I Kunitsyn4672717 C Moyá477746
  M Zabaleta224    P Kohlschreiber656564
  P Kohlschreiber666    P Kohlschreiber3666 
  N Devilder012  11 M Youzhny6433 
11 M Youzhny666  

Section 6

First RoundSecond RoundThird RoundFourth Round
16 L Hewitt666  
  A Delić242  16 L Hewitt6442 
  A Seppi4465   A Calleri4666 
  A Calleri6637   A Calleri6524  
Q D Sela5666 23 J Mónaco7766  
  N Lapentti7213 Q D Sela40774 
  É Roger-Vasselin2615 23 J Mónaco66616 
23 J Mónaco6367 23 J Mónaco562781 
31 J Melzer677  3 N Djokovic777666 
  D Hartfield455  31 J Melzer314  
  JM del Potro666    JM del Potro666  
  N Mahut042    JM del Potro134  
  C Berlocq637742 3 N Djokovic666  
  R Štěpánek776466   R Štěpánek77657562
LL R Haase213  3 N Djokovic64775777
3 N Djokovic666  

Section 7

First RoundSecond RoundThird RoundFourth Round
7 F González41674
  T Gabashvili66356  T Gabashvili231  
  R Ginepri666    R Ginepri666  
  O Rochus031    R Ginepri74643
  S Wawrinka46467  S Wawrinka56466
  E Korolev63645  S Wawrinka666  
Q F Dancevic56567  25 M Safin333  
25 M Safin77779    S Wawrinka626664
20 JI Chela6677  20 JI Chela467816
WC M McClune2160  20 JI Chela667  
  D Udomchoke7731662WC W Odesnik315  
WC W Odesnik626637720 JI Chela665266
Q A Pavel3667 12 I Ljubičić477633
Q D Meffert6325 Q A Pavel3466  
  K Vliegen1611  12 I Ljubičić6678  
12 I Ljubičić6776  

Section 8

First RoundSecond RoundThird RoundFourth Round
15 D Ferrer666  
  F Mayer323  15 D Ferrer4666 
  F Serra637766   F Serra6332 
  W Eschauer776242 15 D Ferrer634777
  X Malisse66567 24 D Nalbandian366655
  K Pless47735   X Malisse442  
  I Navarro56466  24 D Nalbandian666  
24 D Nalbandian77778  15 D Ferrer636776 
27 D Tursunov4634 2 R Nadal774642 
  T Henman6366   T Henman62654 
  J-W Tsonga766    J-W Tsonga77276 
  Ó Hernández513    J-W Tsonga6321  
  J Tipsarević5666 2 R Nadal7766  
WC R Sweeting7242   J Tipsarević232r 
WC A Jones5641 2 R Nadal663  
2 R Nadal7366